Paracetamol

Paracetamol

Clinical data
Tred names	Tylenol (USA), Anacin Aspirin Free (USA), Apra (USA), Crocin (Indie), Feverall (USA), Genapap (USA), Panadol (UK), Panadol (Australie), Panodil (Denmark), Efferalgan (Fraunce), Doliprane (Fraunce) Dafalgan (Fraunce) Alvedon (Swaden)
AHFS/Drugs.com	monograph
MedlinePlus	a681004
Leecence data	US FDA: Acetaminophen
Pregnancy category	AU: A US: B (Na risk in non-human studies) safe
Routes o admeenistration	Oral, rectal, intravenous
ATC code	N02BE01 (WHO)
Legal status
Legal status	AU: Unscheduled UK: General sales leet (GSL, OTC) US: OTC
Pharmacokinetic data
Bioavailability	~100%
Metabolism	90 tae 95% Hepatic
Biological hauf-life	1–4 h
Excretion	Renal
Identifiers
IUPAC name N-(4-hydroxyphenyl)ethanamide N-(4-hydroxyphenyl)acetamide
CAS Nummer	103-90-2 Y
PubChem CID	1983
DrugBank	DB00316 Y
ChemSpider	1906 Y
UNII	362O9ITL9D
KEGG	D00217 Y
ChEBI	CHEBI:46195 Y
ChEMBL	CHEMBL112 Y
ECHA InfoCard	100.002.870
Chemical and physical data
Formula	C8H9NO2
Molar mass	151.17 g/mol
3D model (Jmol)	Interactive eemage
Density	1.263 g/cm3
Meltin pynt	169 °C (336 °F)
Solubility in watter	12.78 mg/mL (20 °C)
SMILES CC(=O)Nc1ccc(cc1)O
InChI InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) Y Key:RZVAJINKPMORJF-UHFFFAOYSA-N Y
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Paracetamol INN (/ˌpærəˈsiːtəmɒl/ or /ˌpærəˈsɛtəmɒl/), or acetaminophen USAN ⁱ/əˌsiːtəˈmɪnəfᵻn/, chemically named N-acetyl-p-aminophenol, is a widely uised ower-the-coonter analgesic (pain reliever) an antipyretic (fiver reducer).

Paracetamol is clessifee'd as a mild analgesic. It is commonly uised for the relief o heidaches an ither minor aches an pains an is a major ingredient in numerous cauld an flu remedies. In combination wi opioid analgesics, paracetamol can an aa be uised in the management o mair severe pain sic as post-surgical pain an providin palliative care in advanced cancer patients. Tho acetaminophen is uised tae treat inflammatory pain, it is nae generally clessifee'd as an NSAID acause it exhibits anly waik anti-inflammatory activity.

The onset o analgesia is approximately 11-29.5 minutes efter oral admeenistration o paracetamol, an its hauf-life is 1–4 oors. While generally safe for uise at recommendit doses (1,000 mg per single dose an up tae 4,000 mg per day for adults), acute owerdoses o paracetamol can cause potentially fatal neer, brain an liver damage an, in rare individuals, a normal dose can dae the same. The risk mey be hichtened bi chronic alcohol abuse. Paracetamol toxicity Archived 2018-10-11 at the Wayback Machine is the foremost cause o acute liver failure in the Wastren warld, an accoonts for maist drug owerdoses in the Unitit States, the Unitit Kinrick, Australie an New Zealand.

It is the active metabolite o the coal tar–derived phenacetin, ance popular as an analgesic an antipyretic in its awn richt. Houiver, unlik phenacetin an its combinations, paracetamol is nae considered carcinogenic at therapeutic doses. The wirds acetaminophen (uised in the Unitit States, Canadae, Japan, Sooth Korea, Hong Kong, an Iran) an paracetamol (uised elsewhaur) baith come frae a chemical name for the compoond: para-acetylaminophenol an para-acetylaminophenol. In some contexts, it is simply abbreviated as APAP, for acetyl-para-aminophenol.