Santa Barbara (spænska: Santa Bárbara) er strandborg í Santa Barbara-sýslu, Kaliforníu í Bandaríkjunum.
Íbúafjöldinn árið 2020 var 88.665. Í suðaustri liggur Los Angeles 160 km frá borginni og 525 km í norðvestri finnst San Francisco.
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