阿尔茲海默病(拉丁语:morbus Alzheimer;德语:Alzheimer-Krankheit;英语:Alzheimer's disease),俗称“老年痴懛”,貤有叫伊認知障礙症个,是一種发病进程缓慢、随著辰光推延不断恶化个持续性神经功能障碍。
德国精神病学家爱罗斯·阿尔兹海默来拉1907年顶早报告隻毛病,由此命名。
病因至今不明。比较行个假说有得“β类淀粉样蛋白堆积”、“τ蛋白异常导致神经纤维纠结”咾啥,但是多年来基于箇方面个新药开发几乎全军覆没。Joel T. Dudley团队基于944隻大脑样本分析显示,患者搭健康人个基因表达明显两样,外加搭疱疹病毒感染搭界。Liang Oscar Qiang则发现,τ蛋白好保持微管动态生长,而不像老早认为个保持微管稳定。
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