Serotoninum: Compositum chemicum

In corpore humano a multis membris (iecore, liene, systemate nervoso centrali) effunditur.

Biochemia

Synthesis biochemica

Synthesis biologica serotonini gradibus duobus accidit, primo hydroxylatione tryptophani deinde decarboxylatione 5-hydroxytryptophani.

Tryptophani hydroxylasis (tryptophanum)

Tryptophanum, acidum aminicum, est substantia initialis. In enzymi tryptophani hydroxylasis praesentia tryptophano grex hydroxidi (-OH, oxygenium cum hydrogenio) additur. Enzymum tryptophani hydroxylasis (TPH 1 et -solum in cerebro- TPH 2) cum cofactore Fe⁺⁺ in communione cum sapropterino et oxygenio (O₂) aliud acidum aminicum chemicum, quod 5-hydroxytryptophanum nominatur, format.

Decarboxylasis acidorum aminicorum aromaticorum (5-hydroxytryptophanum)

5-hydroxytryptophanum tunc decarboxylasi acidorum aminicorum aromaticorum carbonii dioxidum (CO₂) reddit, ideo structura acidi aminici sua perdit. Substantia chemica nova est 5-hydroxytryptaminum, sive serotoninum. Cofactor est vitaminum B₆ (PLP, pyridoxali 5'-phosphatum).

Syndroma serotonergicum

Saepe syndroma hoc effectus secundarius medicamentis quae systema serotonergicum attingunt. Symptomata sunt:

Febris
Symptomata generalia nervorum musculorumque (myocloni, tremor, rigiditas musculorum; capitis dolor)
Mala mentis (delirium)

Notae

Nexus interni

Nexus externus

De serotonini catabolismo

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