March 11 – The Parliament of Bohemia adopts a new constitution that limits the power of King Vladislav II and subsequent Bohemian monarchs. Miroslav Buchvaldek, Československé dějiny v datech ("Czechoslovak History and Data") (Svoboda, 1987)
March 24 – The day after departing the Cape Verde Islands with the rest of Cabral's fleet, Vasco de Ataíde and his 150 crewmates die when their ship goes down in a storm.
May 1 – Pêro Vaz de Caminha finishes writing his chronicle of the Portuguese discovery of Brazil while accompanying Cabral.
May 3 – Cabral and his fleet depart from Brazil and sail eastward toward Africa, resuming their journey to India.
May 5 – Representatives of the English and Spanish royal families sign a treaty at Canterbury for the marriage of 13-year-old Arthur, Prince of Wales (son of King Henry VII and Elizabeth of York) to 14-year-old Princess Catherine of Aragon. Arthur's marriage to Catherine takes place the next year, but Arthur dies five months later; she marries Arthur's younger brother Henry VIII in 1509.
May 29 – Traveling eastward from Brazil, Cabral and his fleet run into a storm off of the coast of Africa near the Cape of Good Hope and lose four of their 13 ships. Navigator Bartolomeu Dias is among the persons killed.
August 10 – Diogo Dias discovers an island which he names São Lourenço, since August 10 is the feast day of Saint Lawrence, a Roman Catholic martyr of the 3rd century. The massive island is later known as Madagascar.
September 13 – Pedro Cabral's fleet of nine ships arrives in India, more than six months after departing from Portugal, and lands at the port of Calicut, which had been visited two years earlier by Vasco da Gama.
September 15 – Christopher Columbus (Cristobal Colon) is placed under arrest, along with his two brothers, Bartolome and Diego, after appearing before Francisco de Bobadilla, who had replaced him as the Spanish Governor of the New World. ("El 15 de septiemre Bobadilla presenta sus credenciales a Colon... Colon habia ejectuado a varios espanoles cargo de gran peso contra el, asi que al fin Bobadilla resolvio enviarlos presos a Espana para que alla se les juzgase."— "On the 15th of September of 1500, Bobadilla presented his credential to Columbus. Columbus had executed several Spaniards charged with great weight against him, so Bobadilla finally decided to send them prisoners to Spain so that they could be tried there.")
September 23 – Bobadilla hears testimony from 22 witnesses and concludes that the Columbus brothers intended to overthrow him; he has them placed in manacles and chains for deportation to Spain. ("La pesquisa de Bobadilla contra Colon habia comenzado el 23-IX-1500."— "Bobadilla's investigation against Colon had begun on 23 September 1500.")
October–December
October 1 – Christopher Columbus and his brothers, arrested and in chains, are deported from Santo Domingo to Spain.
October 22 – Nasir-ud-Din Shah overthrows the government of his father, Ghiyath Shah, ruler of the Malwa Sultanate (located in much of what is now the Indian state of Andhra Pradesh) for the last 31 years. Upon becoming the new Sultan, Nasir has his brother Ala-ud-Din executed, along with Ala-ud-din's children. Ghiyasuddin is poisoned the following February.
November 25 – Christopher Columbus and his brothers arrive in Spain at Seville "after one of the longest Atlantic crossings in the Columbian years" (six weeks) and released on their own recognizance.
December 17 – All charges against the Columbus brothers for malfeasance in governing Hispanola are dismissed by King Ferdinand and Queen Isabella.
Although other reports exist, it is thought that the last wolf in England was killed this year, making the species extinct in that country. The wolf is thought to have been killed in Allithwaite, in Cumbria. However, reports of wolf sightings and laws concerning wolf bounties existed in rural areas of the north until the 18th century.
A group of Māori migrated east from the New Zealand mainland to the Chatham Islands, developing a distinct pacificist culture known as the Moriori (approx date)
February 1 – The Duchy of Bavaria-Dachau, created in Germany in 1467 after Sigismund, Duke of Bavaria was granted his own state following his resignation from the throne of the Duchy of Bavaria-Munich, reverts to Bavaria-Munich's control upon Sigismund's death.
March 4 – Minkhaung II becomes the sole King of Burma upon the death of his son Thihathura II, with whom he was co-ruler for 15 years. Minkhaung's reign ends five weeks later when he dies on April 7.
July 21 – Portuguese explorer Pedro Álvares Cabral and his surviving crew return to Lisbon at the end of a 15-month expedition to India, with only seven of their original fleet of 13 ships. The cargo from India, however, returns a profit to the Portuguese crown of nine times its investment.
September 3 – On complaints from Christopher Columbus, who had been replaced as Viceroy of the New World and arrested in 1500 by Francisco de Bobadilla, Queen Isabella of Spain orders that Bobadilla be recalled from Santo Domingo. Declining to allow Columbus to resume his brutal rule of the New World, the Queen appoints a friend, Nicolás de Ovando, as the new Viceroy. Although Bobadilla receives news of his firing several weeks later, he declines to step aside. Ovando will assemble a fleet of 30 ships and depart Spain on February 13 for Santo Domingo.
September 27 – Queen Isabella orders New World Governor Bobadilla to return the assets confiscated from Christopher Columbus and the two other Columbus brothers.
Spanish princess Catherine of Aragon arrives in England and arrives at Plymouth. Although she will later become the wife of King Henry VIII in 1509, she initially arrives to marry Henry's older brother, Prince Arthur.
November 12 – Sten Sture the Elder is elected Regent of Sweden for the second time, becoming the Scandinavian nation's chief executive after King Hans of Denmark is deposed. No replacement of the monarchy is planned by the rebel Swedish nobles.
January 24 – Commissioners from Scotland and England meet at Richmond Palace in London to finalize an agreement on the marriage between Scotland's King James IV to the daughter of England's King Henry VII, the princess Margaret Tudor, with a dowry of 35,000 Scottish Punnds and an agreement for a "treaty of perpetual peace". The marriage will be completed by proxy on January 25, 1503.
April 2 – Arthur, Prince of Wales, the 15-year-old Duke of Cornwall and Earl of Chester, heir to the English throne as eldest son of King Henry VII, dies of a long illness less than five months marrying Catherine of Aragon. Arthur's 10-year-old brother, Henry, Duke of York, becomes the new heir to the throne and will later succeed his father as King Henry VIII.
April 14 – The formal coronation of Ivan the Great as Grand Prince of Moscow (encompassing most of the Russian people's territory) to reflect that he is the nation's sole ruler. Ivan had been co-ruler of Moscow from 1449 to 1462, ruler from 1462 to 1471 and 1490 to 1498, and co-ruler with his eldest son (Ivan the Young, 1471-1490) and his grandson, Dmitry Ivanovich from 1498 onward.
May 9 – Christopher Columbus leaves Cadiz in Spain for his fourth and final trip to the New World, taking with him 147 men on his flagship, Capitana and the companion ships Gallega, Vizcaína, and Santiago de Palos. He explores Central America, and discovers the Isthmus of Panama and the land now occupied by Honduras, and Costa Rica, and possibly the island of St. Lucia as well
May 26 – Columbus and his men complete the rescue of stranded Portuguese soldiers in Morocco, then depart Asilah for a crossing of the Atlantic in 20 days.
June 29 – Columbus and his crew attempt to land at Santo Domingo in order to avoid being caught in a hurricane, despite being ordered not to return to Hispaniola. Nicolás de Ovando, the Spanish Viceroy, refuses to let Columbus sail into harbor and does not believe the warnings of the hurricane, which strikes two days later.
July–September
July 1 – A powerful hurricane sweeps through the Caribbean Sea near Puerto Rico and the island of Hispaniola, two days after Christopher Columbus was denied permission to land at Santo Domingo. An estimated 500 people are killed when the winds wreck 20 of the 31 ships brought from Spain by the new Viceroy, Nicolás de Ovando, including Ovando's flagship, El Dorado. Former Viceroy Francisco de Bobadilla and administrator Francisco Roldán are among the people killed. A ship provided by Bobadilla for Columbus to transport the gold owed to him, the Aguja, is one of the 11 to survive the hurricane and accusations are made that Columbus magically invoked the storm as an act of vengeance.
July 28 – At Augsburg, Maximilian I, Germany's King of the Romans signs a treaty with representatives of King Henry VII of England, agreeing not to provide assistance to English rebels.
July 30 – The first encounter between Europeans and the Maya people of Central America takes place when the Columbus brothers anchor at Guanaja, one of the Bay Islands off of the coast of what is now the nation of Honduras. An unfortunate group of Mayan traders happens to arrive at Guanaja at the same time, and its cargo is looted by Bartolomeo Columbus and his crew.
December 31 – Cesare Borgia (son of Pope Alexander VI) occupies Urbino, where he imprisons two potentially treacherous allies, Vitellozzo and Oliveretto; he executes them the next morning.
June 21 – Murad, the last Sultan of Aq Qoyunlu in what is now eastern Turkey fights the Safavid King of Persia, Ismail I in a battle near the city of Hamadan, and suffers 10,000 casualties, including his commander Güzel Ahmad.
June 25 – After his ships are damaged in a storm, Christopher Columbus and his 230 men are forced to beach at the island of Jamaica (at what is now Saint Ann Parish) and remain stranded there for the next six months.
August 18 – Pope Alexander VI dies after a reign of 11 years, and the largest gathering of cardinals up to that time— 21 from Italy, 11 from Spain and 7 from France— is called to Rome for a papal conclave, to start in September.
August 20 – A previous treaty between Vladislaus II of Hungary and Bayezid II, which was finalized on June 11th, goes into effect. The treaty suppresses warfare along the Hungarian-Ottoman border. Stephen III of Moldavia is also included in this treaty, but it perserves his nation's independence on the condition Moldavia pays an annual tribute to the Ottoman Empire.
September 22 – Francesco Todeschini Piccolomini, Archbishop of Siena, is elected as the new Pope after the voting cardinals cannot decide between Georges d'Amboise of France or Giuliano della Rovere of Italy. Piccolomini takes the name of Pope Pius III but will reign for only 26 days.
November 1 – Cardinal Giuliano della Rovere, Bishop of Ostia, is elected the 216th Roman Catholic Pontiff at the end of the year's second papal conclave and takes the papal name Pope Julius II.: 210 Della Rovere had received 15 of 32 votes in the September voting for a plurality, but still short of a majority.: 89 Julius II reigns for a little more than nine years until his death his death in 1513.: 91
November 29 – Pope Julius II, formerly Giuliano della Rovere, adds four new people to the College of Cardinals, including two members of his family, Clemente della Rovere and Galeotto della Rovere.: 219 By the time of his death, Julius will have added 27 cardinals to the Roman Catholic Church, five of them from the della Rovere family.
March 16 – In what is now India's Kerala state, a second invasion of the Portuguese-supported Kingdom of Cochin by the Zamorin of Calicut takes place, beginning a war that lasts until July 3.
May 24 – Le Hien Tong, Emperor of Vietnam, dies after a reign of six years and is succeeded by his 15-year-old son Le Tuc Tong.
June 17 – Rao Bika Rathore, ruler of the Kingdom of Bikaner in India, dies after a reign of 32 years. For a brief time Bika is succeeded by his elder son Nara, but Nara quickly dies and Nara is succeeded by his brother Lunkaran.
June 28 – After being marooned in Jamaica for six months, Christopher Columbus and his men are rescued by a Spanish ship.
July 3 – The siege of Cochin in India by the invading forces of Calicut ends as the Portuguese and Cochin defenders defeat the invaders. Calicut loses 5,000 dead in battle and another 13,000 to disease, while Cochin and Portugal sustain minimal losses.
July 7 – At the age of 16, Lê Túc Tông becomes the new Emperor of Vietnam (Dai Viet) after the death of his father, Lê Hiến Tông, but serves for only six months before dying.
July 20 – Pope Julius II issues an order reforming the official coinage of the Papal States, raising the silver content of the carlino coin to four grams. In that the Pope was formerly Giuliano della Rovere, the new coin is called the giulio in his honor and features the coat of arms of the della Rovere family.
In Florence, Leonardo da Vinci and Niccolò Machiavelli become involved in a scheme to divert the Arno River, cutting the water supply to Pisa to force its surrender: Colombino, the project foreman, fails to follow da Vinci's design, and the project is a major failure.
January 14 – Pope Julius II issues the papal bull Cum tam divino, decreeing a reform in the Roman Catholic Church to prohibit simony, the buying and selling of church offices ranging from bishops to the pope himself.
January 23 – Lunkaran begins his reign as the Rao of the Indian kingdom of Bikaner in what is now the Rajasthan state of India.
January 24 – Under the terms of the Treaty of Tordesillas, Pope Julius II sets the line of demarcation in the New World between Spain's and Portugal's territory as a line of longitude 370 leagues west of the Cape Verde islands. The ambiguous definition of the measure of a league places the line between 42°30' W to 49°45' W.
March 31 – King Alexander Jagiellon of Poland agrees to support the Act of Nihil novi, prohibiting the king to issue laws without consent of the nobles represented by their parliament, the Sejm. The official title is "Nihil novi nisi commune consensu", Latin for "Nothing new without common consent."
April–June
April 3 – Italian explorer Sebastiano Caboto is granted a lifetime annuity of £10 per year by England's King Henry VII for services "in and aboute the fyndynge of the new founde landes" in North America.
May 30 – Poland's Act of Nihil novi is granted by King Alexander I Jagiellon after being passed by the Sejm, making Poland a Nobles' Democracy rather than an absolute monarchy.
The Kalmar Bloodbath, a mass execution of participants in the Swedish Uprising against King Hans of Denmark (who also rules Norway and Sweden) takes place in the Swedish city of Kalmar after a judgment of treason is pronounced against the mayor, city officials and other leaders.
Martin Luther, aged 22, vows to become a monk in a moment of terror, as a result of a close lightning strike during a thunderstorm, near the village of Stotternheim.
July 24 – Travelling to India, a group of Portuguese explorers led by Francisco de Almeida, with 22 ships and 1,500 men, sack the city-state of Kilwa in East Africa, killing the Emir Abraham for failing to pay tribute. Almeida installs Mohammed Ankoni as the new ruler.
Francisco de Almeida arrives in the Anjediva Islands to begin construction on the first of four fortresses he needed to construct for his appointment as viceroy.
November 15 – Portuguese explorer Lourenço de Almeida and his fleet encounter a storm and are driven to the island of Sri Lanka and travels to Colombo. The King of Kotte, Dharma Parakramabahu IX, allows Almeida to build a trade station and a Roman Catholic chapel.
The Pomander Watch of 1505, the earliest known pocket watch, is made by Peter Henlein in Germany at Nuremberg. After an absence of 480 years, the watch will be rediscovered at a flea market in London; an inscription on the watch, "MDVPHN", will be interpreted in 2014 as meaning a rendition of the year (MDV, 1505 in Roman numerals); the inventor (PH for Peter Henlein) and the place of manufacture (N for Nuremberg).
Portuguese merchants establish factories and fortresses on the east coast of Africa in Kilwa, Sofala, and Malindi.
February 15 – Iye Roy Mackay, Chief of Scotland's Clan Mackay, records his 1504 grant of six lands in what is now the County Sutherland, and starts a feud with Euphemia II, Countess of Ross.
March 16 – Battle of Cannanore: Portugal's fleet (commanded by Lourenço de Almeida) defeats the fleet of the Zamorin of Calicut, with hundreds of vessels involved; 3,000 Muslim troops are killed.
May 28 – Emperor Moctezuma II of Mexico's Aztec Empire subdues a rebellion in Zozollan, east of Achiutia, then kills the prisoners of war as a sacrifice to the gods.
July 12 – Philip the Fair, Duke of Burgundy, becomes the ruler of the Spanish Kingdom of Castile with his insane wife Joanna, but reigns for only two months before dying of typhoid.
September 25 – Philip I, the first Spanish Habsburg King of Castile, dies suddenly from typhoid.
October–December
October 6 – In Córdoba, in the Spanish kingdom of Andalusia, members of the nobility and the general public revolt against the Spanish inquisitor Diego Rodriguez de Lucero and General Inquisitor Diego de Deza. The mob liberates the people incarcerated at the Córdoba prison.
October 7 – Pope Julius II issues a bull excommunicating Giovanni II Bentivoglio from the Roman Catholic Church, who had dominated the Italian city state of Bologna.
February 9 – The crew of the Portuguese ship Cirne, commanded by Diogo Fernandes Pereira, become the first Europeans to sight the Indian ocean island of Réunion, and name it Santa Apolonia.
March 1 – Eleven months after the Lisbon Massacre, King Manuel I of Portugal issues an edict permitting the cristãos-novos ("New Christians", Portuguese Jews who had been forced to convert to Christianity) to freely emigrate from the kingdom.
March 11 – Italian mercenary leader and former prince Cesare Borgia, later cited by Niccolò Machiavelli in The Prince as an example of "conquest by fortune", completes his conquest of the Spanish city of Viana by driving out the defenders of the castle of the Count of Lerín, but makes the mistake of pursuing the fleeing enemy by himself. He is killed the next day by his captors.
March 28 – The revolutionary council of the Republic of Genoa declares a war against French invaders.: 83
April 10 – Installed by the Revolutionary Council, Paolo da Novi becomes the first Doge of the Republic of Genoa in almost 19 years, after the office had been made vacant in 1488 by the conqueror Francesco Sforza. He reigns for only 18 days before fleeing from office by French occupation forces on April 28, and the dogeship will remain vacant again for five years.
In India, in what is now the state of Kerala, troops from the Kingdom of Cannanore begin a four-month siege of the Portuguese garrison at the Fort of Saint Angelo. Despite being outnumbered, the 150 defenders of the fort hold out for four months against 60,000 attackers until rescue arrives four months later.
In Italy, King Louis XII of France departs from Genoa: 85 and makes a triumphant entry into Milan on May 24.
June 4 – Having been denied recognition by Pope Julius II as King of Naples, King Ferdinand II of Aragon departs from Naples to return to his home in Spain.
June 28 – King Ferdinand II of Aragon is welcomed by King Louis XII of France at the Italian city of Savona in a spectacular ceremony, and the two monarchs begin a series of meetings on the division of the Italian kingdoms between France and Spain.
July—September
July 3 – King Ferdinand II of Aragon and King Louis XII of France complete their six-day summit at Savona.
August 10 – Afonso de Albuquerque departs with six ships from the Yemeni island of Socotra to begin pillaging towns along the way to conquering the Persian Gulf port of Hormuz.
September 15 – King James IV grants a patent for the first printing press in Scotland, to Walter Chapman and Andrew Myllar "to furnis and bring hame ane prent, with all stuff belangand tharto, and expert men to use the samyne, for imprenting within our Realme of the bukis of our Lawis, actis of parliament, croniclis, mess bukis, and portuus efter the use of our Realme, with addicions and legendis of Scottis sanctis, now gaderit to be ekit tharto, and al utheris bukis that salbe sene necessar, and to sel the sammyn for competent pricis."
November 24 – Portuguese Admiral Tristao da Cunha, with 12 ships, attacks a fleet of 13 Muslim merchant ships leaving the Indian port of Ponnani, and is confronted by the forces of Kutti Ali. The Portuguese win the battle.
June 6 – Holy Roman Emperor Maximilian I signs a humiliating armistice with the Republic of Venice, which for the moment stops any of his further plans for Italy.
July–September
July 23 – Upon the death of his father, King Oxlahuh-Tz'i, Hun-Iqʼ becomes one of the two kings of Guatemala's KaqchikelMaya civilization. Hun-Iqʼ reigns jointly with King Kablahuh-Tihax until the latter's death on February 4.
July 27 – The process of removing the former layers of paint on the ceiling of the Sistine Chapel is completed, and Michelangelo begins the next phase of marking the surface for painting.
July 31 – The Emperor of Ethiopia, Na'od, dies in battle. His son Lebna Dengel takes on the regnal name of Dawit II, and becomes the new emperor starting on August 11.
August 12 – The Spanish settlement of Puerto Rico begins when Juan Ponce de León lands on the island. Upon his arrival, Ponce is welcomed by Agüeybaná I, the island's leader a Cacique of the Taíno people. The Spanish explorer soon settles and founds the city of Caparra, near what is now the town of Guaynabo.
September 27 – A violent storm ravages the Dutch coast, killing potentially thousands of people.
October–December
October 2 – The siege of Padua ends with Venetian victory, causing the retreat of HRE and French forces back to Tyrol and Milan. The Venetians soon recapture the city of Vicenza.
November 10 – Uriel von Gemmingen is assigned to secure others' opinions before continuing the Jewish book purge started on August 19th.
December 1 – Prince Le Oanh is installed as the new Emperor of Vietnam by a coup d'etat against his cousin, Emperor Le Uy Muc, and is enthroned at the age of 14 as Emperor Le Tuong Duc. Uy Muc is granted his request to be allowed to commit suicide rather than to be executed.
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