February 6 – Pope Gregory XIII issues the papal bull Illius fulti praesidio and creates the Diocese of Manila, the first Roman Catholic diocese in the Philippines, with Domingo de Salazar as the first Bishop of Manila. The diocese will be raised to the status of archdiocese on August 14, 1595.
February 12 – Mohammad Khodabanda, older brother of the late Shah Ismail II, begins his reign as the new Shah of Persia (now Iran) after entering the Persian capital at Qazvin, after removing his sister Pari Khan Khanum, who had exercised regal authority after Ismail's death. His first act as ruler is to have Pari Khan Khanum strangled to death.
February 13 – Two days after the Battle of Gembloux, Spanish troops capture the city of Leuven, forcing Willem, Prince of Orange, to flee Brussels and relocate to Antwerp.Geoffrey Parker, The Dutch Revolt (Cornell University Press, 1977) p.186
James Douglas, 4th Earl of Morton, the last of the regents for King James VI of Scotland, resigns after having served as regent since November 24, 1572.
The Belgian city of Bruges, controlled by Spain, falls to Dutch rebels.
May 26 – The Alteratie takes place in Amsterdam, expelling the 24 Catholic members of the 40-man city government, and forming a new council is formed with 30 Calvinist Protestants and 10 Catholics.
June 30 – After having come into conflict on May 17 with his fellow officer, Thomas Doughty, during their circumnavigation of the world, Francis Drake puts Doughty on trial while the flagship Pelican is docked at what is now Argentina. A jury of sailors convicts Doughty of treason and attempted mutiny. Doughty is beheaded on July 2.
July–September
July 2 – The Frobisher expedition reaches Canada and enters what is now Frobisher Bay. One of the ships, the Dennis, is wrecked on an iceberg.
At the Battle of Rijmenam, fought near Antwerp in what is now Belgium, a combined Dutch and English force under the command of the Count of Boussu and England's John Norreys defeats Spanish troops commanded by Don Juan de Austria.
According to some accounts, Englishman Martin Frobisher holds the first Thanksgiving celebration by Europeans in Canada, on Newfoundland, after he and his fleet encounter two ships that they feared had been lost. However, the celebration involves no feast and is limited to a sermon by the expedition's minister and Frobisher's men giving praise.
August 31 – The Forbisher expedition departs North America for its journey back to England.
September 6 – After 16 days travel, the fleet of Francis Drake completes its traverse of the Strait of Magellan between the tip of South America and Tierra del Fuego. Upon entering the Pacific Ocean, the fleet encounters violent storms. The supply ship Marigold, with over 100 men under the command of John Thomas, is lost with all hands off of Cape Horn. The rest of the fleet continues its voyage around the world.
November 19 – Humphrey Gilbert and Walter Ralegh set out from Plymouth in England, leading an expedition to establish a colony in North America. They will be forced to turn back six months later.
December 9 – After more than five years of combat in southern France, the Protestant Huguenot citadel of Ménerbes negotiates a surrender to its French Catholic attackers.
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