February 1 – The Duchy of Bavaria-Dachau, created in Germany in 1467 after Sigismund, Duke of Bavaria was granted his own state following his resignation from the throne of the Duchy of Bavaria-Munich, reverts to Bavaria-Munich's control upon Sigismund's death.
March 4 – Minkhaung II becomes the sole King of Burma upon the death of his son Thihathura II, with whom he was co-ruler for 15 years. Minkhaung's reign ends five weeks later when he dies on April 7.
July 21 – Portuguese explorer Pedro Álvares Cabral and his surviving crew return to Lisbon at the end of a 15-month expedition to India, with only seven of their original fleet of 13 ships. The cargo from India, however, returns a profit to the Portuguese crown of nine times its investment.
September 3 – On complaints from Christopher Columbus, who had been replaced as Viceroy of the New World and arrested in 1500 by Francisco de Bobadilla, Queen Isabella of Spain orders that Bobadilla be recalled from Santo Domingo. Declining to allow Columbus to resume his brutal rule of the New World, the Queen appoints a friend, Nicolás de Ovando, as the new Viceroy. Although Bobadilla receives news of his firing several weeks later, he declines to step aside. Ovando will assemble a fleet of 30 ships and depart Spain on February 13 for Santo Domingo.
September 27 – Queen Isabella orders New World Governor Bobadilla to return the assets confiscated from Christopher Columbus and the two other Columbus brothers.
Spanish princess Catherine of Aragon arrives in England and arrives at Plymouth. Although she will later become the wife of King Henry VIII in 1509, she initially arrives to marry Henry's older brother, Prince Arthur.
November 12 – Sten Sture the Elder is elected Regent of Sweden for the second time, becoming the Scandinavian nation's chief executive after King Hans of Denmark is deposed. No replacement of the monarchy is planned by the rebel Swedish nobles.
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