Events
Births
- March 21 – Hermann Finck, German composer and music theorist (died 1558)
- April 14 – Abraham Ortelius, cartographer and geographer (died 1598)
- July 13 – John Dee, English mathematician, astronomer, and geographer (died 1608)
- July 31 – Maximilian II, Holy Roman Emperor (died 1576)
- Giuseppe Arcimboldo, Italian artist (died 1593)
- Charles of Guise, French Cardinal and member of the powerful House of Guise (died 1574)
- Lawrence Humphrey, president of Magdalen College, Oxford (died 1590)
- Luis Ponce de León, Spanish lyric poet (died 1591)
- Sakuma Nobumori, Japanese retainer and samurai (died 1581)
- Annibale Padovano, Italian composer and organist (died 1575)
- Philip II of Spain
Deaths
- January 21 – Juan de Grijalva, Spanish conquistador (born 1489)
- June 21 – Niccolò Machiavelli, Italian writer and statesman (born 1469)
- July 28 – Rodrigo de Bastidas, Spanish conquistador and explorer (born 1460)
- Boabdil, last Moorish king of Granada (of the Nasrid dynasty)
- Charles III, Duke of Bourbon, Count of Montpensier and Dauphin of Auvergne (born 1490)
- Francesco Colonna, Italian Dominican priest (born 1433)
- Thomas Docwra, Grand Prior of the Knights Hospitaller (born 1458)
- Felix Manz, co-founder of the original Swiss Brethren Anabaptist congregation in Zürich
- Cristoforo Solari, Italian sculptor and architect
- Jan "Ciezki" Tarnowski, Polish nobleman
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