圣地亚哥,全称圣地亚哥-德古巴(西班牙语:Santiago de Cuba,意为古巴个圣地亚哥),垃拉古巴东南部,是圣地亚哥省个首府,也是古巴第二大城市搭重要海港,面积1,023.8平方公里,人口494,337(2004年)。
该市有得联合国教科文组织世界遗产圣佩德罗德拉罗卡城堡。
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