Santiago de Cuba es li duesim max grand cité de Cuba.
It es situat in li sud-ost del insul e es li cité capital del Provincia Santiago de Cuba.
Li cité have 506.037 (2012) habitantes e un area de 1.032,29 quadrat-kilometres.
Santiago de Cuba esset fundat in li annu 1515 de Diego Velázquez de Cuéllar. Li 1-im de januar 1984 Fidel Castro dat li cité li honor-titul héroe-cité del Republica Cuba pro su merites in li comunist revolution.
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