Antiinflammatorium Nonsteroidale
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Antiinflammatoria nonsteroidalia, breve AINS sunt familia medicamentorum, quae per inhibitionem enzymorum cyclooxygenasium - deinde inhibitione synthesis prostaglandinorum effectus suos contra inflammationem (=anti-inflammativos) efficiunt.
Effectus adversi sunt nephropathiae, ulcera gastrointestinalia, reactiones allergicae (ut bronchoconstrictio, angiooedema, urticaria, dermatitis), etiam infarctus cordis.
Exempla AINS
- Ibuprofenum
- Diclofenac
- Naproxenum
- Coxiba
- Celecoxibum
- Etoricoxibum
Historia
Annis 1960 ineunte effectus adversarii glucocorticoidorum, quae tum saepe in inflammationes tractandi usa erant, cognoscebantur. Cum familia nova antiinflammatoriorum non-steroidalium medicina et pharmacologia fiduciam recuperari conabantur.
Notae
Nexus interni
Nexus externi
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