팀 헌트
팀 헌트 기사(영어: Sir Tim Hunt, FRS, 1943년 2월 19일 ~ )은 영국의 생화학자이다. 2001년에 세포 주기의 핵심 조절 인자를 발견한 공로로 릴런드 H. 하트웰, 폴 너스와 함께 노벨 생리학·의학상을 수상했다.
| 팀 헌트  Richard Timothy Hunt | |
.jpg) 팀 헌트 (2009년) | |
| 출생 | 1943년 2월 19일(81세) 잉글랜드 체셔주 네스턴 |
|---|---|
| 주요 업적 | 세포 주기 연구 |
| 수상 |
|
| 분야 | 생화학 |
| 소속 |
|
| 박사 교수 | 애셔 코너 |
| 박사 학생 | 휴 펠럼 조너선 파인즈 |
상훈
- 2001년: 노벨 생리학·의학상
- 2006년: 로열 메달
- 2006년: 기사작위(Knight Bachelor) 서임
회원
주요 저서
- Mochida, Satoru; Maslen, Sarah L; Skehel, Mark; Hunt, Tim (2010). “Greatwall phosphorylates an inhibitor of protein phosphatase 2Α that is essential for mitosis”. 《Science》 330 (6011): 1670–1673. doi:10.1126/science.1195689. PMID 21164013.
- Mochida, Satoru; Hunt, Tim (2007). “Calcineurin is required to release Xenopus egg extracts from meiotic M phase”. 《Nature》 449: 336–340. doi:10.1038/nature06121. PMID 17882219.
- Rouse, John; Cohen, Philip; Trigon, Sylviane; Morange, Michel; Alonso-Llamazares, Ana; Zamanillo, Daniel; Hunt, Tim; Nebreda, Angel R. (1994). “A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins”. 《Cell》 78 (6): 1027–1037. doi:10.1016/0092-8674(94)90277-1. ISSN 0092-8674. PMID 7923353.
- Evans, Tom; Rosenthal, Eric T.; Youngblom, Jim; Distel, Dan; Hunt, Tim (1983). “Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division”. 《Cell》 33 (2): 389–396. doi:10.1016/0092-8674(83)90420-8. ISSN 0092-8674. PMID 6134587.
- Farrell, Paul J.; Balkow, Ken; Hunt, Tim; Jackson, Richard J.; Trachsel, Hans (1977). “Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis”. 《Cell》 11 (1): 187–200. doi:10.1016/0092-8674(77)90330-0. ISSN 0092-8674. PMID 559547.
- Poon, R. Y.; Yamashita, K.; Adamczewski, J. P.; Hunt, T.; Shuttleworth, J. (1993). “The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2”. 《EMBO Journal》 12: 3123–3132. PMC 413578. PMID 8393783.
- Nebreda, A.R.; Hunt, T. (1993). “The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs”. 《EMBO J》 12: 1979–1986. PMC 413419. PMID 8387916.
- Craig, D.; Howell, M.T.; Gibbs, C.L.; Hunt, T.; Jackson, R.J. (1992). “Plasmid cDNA-directed protein synthesis in a couple eukaryotic in vitro transcription-translation system”. 《Nucleic Acids Res.》 20: 4987–4995. doi:10.1093/nar/20.19.4987. PMC 334274. PMID 1383935.
- Standart, N.; Dale, M.; Stewart, E.; Hunt, T. (1990). “Maternal mRNA from clam oocytes can be specifically unmasked in vitro by antisense RNA complementary to the 3’ untranslated region”. 《Genes Dev.》 4: 2157–2168. doi:10.1101/gad.4.12a.2157. PMID 2148535.
- Gautier, J.; Minshull, J.; Lohka, M.; Glotzer, M.; Hunt, T.; Maller, J.L. (1990). “Cyclin is a component of MPF from Xenopus”. 《Cell》 60: 487–494. doi:10.1016/0092-8674(90)90599-a. PMID 1967981.
- Standart, N.; Minshull, J.; Pines, J.; Hunt, T. (1987). “Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte”. 《Dev. Biol.》 124: 248–258. doi:10.1016/0012-1606(87)90476-3. PMID 15669148.
- Minshull, J.; Hunt, T. (1986). “The use of single-stranded DNA and RNase H to promote quantitative ‘hybrid arrest of translation’ of mRNA/DNA hybrids in reticulocyte lysate cell-free translations”. 《Nucleic Acids Res.》 14: 6433–6451. doi:10.1093/nar/14.16.6433. PMC 311656. PMID 3018671.
- Hunt, T.; Herbert, P.; Campbell, E.A.; Delidakis, C.; Jackson, R.J. (1983). “The use of affinity chromatography on 2'-5'ADP- Sepharose reveals a requirement for NADPH, thioredoxin and thioredoxin reductase for the maintenance of high protein synthesis activity in rabbit reticulocyte lysates”. 《Eur. J. Biochem.》 131: 303–311. doi:10.1111/j.1432-1033.1983.tb07263.x. PMID 6299735.
- Rosenthal, E.T.; Hunt, T.; Ruderman, J.V. (1980). “Selective translation of mRNA controls the pattern of protein synthesis during early development of the surf clam, Spisula solidissima”. 《Cell》 20: 487–494. doi:10.1016/0092-8674(80)90635-2. PMID 7190072.
- Hunter, A.R.; Hunt, T.; Knowland, J.S.; Zimmern, D. (1976). “Messenger RNA for the coat protein of tobacco mosaic virus”. 《Nature》 260: 759–764. doi:10.1038/260759a0. PMID 1264250.
- Darnbrough, C.H.; Legon, S.; Hunt, T.; Jackson, R.J. (1973). “Initiation of protein synthesis: evidence for messenger RNA- independent binding of methionyl transfer RNA to the 40S ribosomal subunit”. 《J. Mol. Biol.》 76: 379–403. doi:10.1016/0022-2836(73)90511-1. PMID 4732074.
- Kosower, N.S.; Vanderhoff, G.A.; Benerofe, B.; Hunt, T.; Kosower, E.M. (1971). “Inhibition of protein synthesis by glutathione disulfide in the presence of glutathione”. 《Biochem. Biophys. Res. Commun.》 45: 816–821. doi:10.1016/0006-291x(71)90490-6. PMID 5128185.
- Ehrenfeld, E.; Hunt, T. (1971). “Double-stranded poliovirus RNA inhibits initiation of protein synthesis by reticulocyte lysates”. 《Proc. Natl. Acad. Sci. USA》 68: 1075–1078. doi:10.1073/pnas.68.5.1075. PMC 389116. PMID 4325000.
- Hunt, T.; Hunter, A.R.; Munro, A.J. (1968). “Control of haemoglobin synthesis: distribution of ribosomes on the messenger RNA for a and b chains”. 《J. Mol. Biol.》 36: 31–45. doi:10.1016/0022-2836(68)90217-9. PMID 5760537.
- Murray, Andrew; Hunt, Tim (1993). 《The Cell Cycle: An Introduction》. Oxford: Oxford University Press. ISBN 978-0195095296.
- Wilson, John; Hunt, Tim (2014). 《Molecular Biology of the Cell: The Problems Book》 6판. Taylor & Francis Ltd. ISBN 978-0815344537.
각주
외부 링크
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