Ing4
Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.
Function
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.
Interactions
References
Further reading
External links
- ING4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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