Arrestin Beta 1

ARRB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IV8
Identifiers
Aliases	ARRB1, ARB1, ARR1, Arrestin beta 1
External IDs	OMIM: 107940 MGI: 99473 HomoloGene: 2981 GeneCards: ARRB1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	75,351,705 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	99,255,978 bp
RNA expression pattern
	Top expressed in
	monocyte; ; right lung; ; upper lobe of left lung; ; sural nerve; ; prefrontal cortex; ; nucleus accumbens; ; body of stomach; ; gastric mucosa; ; caudate nucleus; ; amygdala;
	Top expressed in
	superior frontal gyrus; ; inferior colliculus; ; molar; ; superior colliculus; ; cerebellar cortex; ; primary motor cortex; ; prefrontal cortex; ; right lung; ; supraoptic nucleus; ; dorsal tegmental nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; histone acetyltransferase activity; enzyme inhibitor activity; insulin-like growth factor receptor binding; transcription factor binding; mitogen-activated protein kinase kinase binding; clathrin adaptor activity; protein phosphorylated amino acid binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; AP-2 adaptor complex binding; alpha-1B adrenergic receptor binding; V2 vasopressin receptor binding; phosphoprotein binding; angiotensin receptor binding; ubiquitin protein ligase binding; arrestin family protein binding; signaling receptor binding; enzyme binding; estrogen receptor binding; alpha-1A adrenergic receptor binding; follicle-stimulating hormone receptor binding; transmembrane transporter binding; clathrin binding; G protein-coupled receptor binding;
Cellular component	cytoplasm; cytosol; postsynaptic membrane; membrane; nucleus; cell projection; dendritic spine; heterotrimeric G-protein complex; chromatin; plasma membrane; intracellular anatomical structure; nucleoplasm; clathrin-coated pit; pseudopodium; postsynaptic density; Golgi membrane; lysosomal membrane; basolateral plasma membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; nuclear body; endosome;
Biological process	positive regulation of Rho protein signal transduction; regulation of G protein-coupled receptor signaling pathway; positive regulation of receptor internalization; transcription by RNA polymerase II; stress fiber assembly; follicle-stimulating hormone signaling pathway; platelet activation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of GTPase activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of insulin secretion involved in cellular response to glucose stimulus; proteasome-mediated ubiquitin-dependent protein catabolic process; phototransduction; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of peptidyl-serine phosphorylation; negative regulation of interleukin-8 production; protein ubiquitination; protein transport; negative regulation of protein phosphorylation; positive regulation of smooth muscle cell apoptotic process; positive regulation of histone H4 acetylation; positive regulation of protein binding; negative regulation of NF-kappaB transcription factor activity; positive regulation of protein ubiquitination; G protein-coupled receptor internalization; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; endocytosis; negative regulation of interleukin-6 production; positive regulation of histone acetylation; negative regulation of protein ubiquitination; negative regulation of ERK1 and ERK2 cascade; negative regulation of signal transduction; positive regulation of transcription by RNA polymerase II; signal transduction; positive regulation of GTPase activity; apoptotic process; membrane organization; regulation of apoptotic process; ubiquitin-dependent protein catabolic process; negative regulation of Notch signaling pathway; G protein-coupled receptor signaling pathway; positive regulation of protein phosphorylation; positive regulation of cell population proliferation; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; histone acetylation;
	Sources:Amigo / QuickGO
Orthologs
	408
	109689
	ENSG00000137486
	ENSMUSG00000018909
	P49407
	Q8BWG8
	NM_004041; NM_020251
	NM_177231; NM_178220
	NP_004032; NP_064647
	NP_796205; NP_835738
	Wikidata
View/Edit Human	View/Edit Mouse

Function

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. Beta-arrestin has been shown to play a role as a scaffold that binds intermediates and may direct G-protein signaling by connecting receptors to clathrin-mediated endocytosis.

Interactions

Arrestin beta 1 has been shown to interact with

Arf6,
PTHLH,
DVL2
Mdm2,
OPRD1,
PSCD2, and
RALGDS.

References

External links

Human ARRB1 genome location and ARRB1 gene details page in the UCSC Genome Browser.

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Arrestin Beta 1

Function

Interactions

References

Further reading

External links

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