Additional Sex Combs Like 2, Transcriptional Regulator
Additional sex combs like 2, transcriptional regulator is a protein that in humans is encoded by the ASXL2 gene.
| ASXL2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | ASXL2, ASXH2, additional sex combs like 2, transcriptional regulator, SHAPNS, ASXL transcriptional regulator 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 612991 MGI: 1922552 HomoloGene: 10102 GeneCards: ASXL2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci. Naturally occurring mutations in this gene are associated with cancer in several tissue types (breast, bladder, pancreas, ovary, prostate, and blood). This gene plays an important role in neurodevelopment, cardiac function, adipogenesis, and osteoclastogenesis.
See also
References
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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