February 15 – Iye Roy Mackay, Chief of Scotland's Clan Mackay, records his 1504 grant of six lands in what is now the County Sutherland, and starts a feud with Euphemia II, Countess of Ross.
March 16 – Battle of Cannanore: Portugal's fleet (commanded by Lourenço de Almeida) defeats the fleet of the Zamorin of Calicut, with hundreds of vessels involved; 3,000 Muslim troops are killed.
May 28 – Emperor Moctezuma II of Mexico's Aztec Empire subdues a rebellion in Zozollan, east of Achiutia, then kills the prisoners of war as a sacrifice to the gods.
July 12 – Philip the Fair, Duke of Burgundy, becomes the ruler of the Spanish Kingdom of Castile with his insane wife Joanna, but reigns for only two months before dying of typhoid.
September 25 – Philip I, the first Spanish Habsburg King of Castile, dies suddenly from typhoid.
October–December
October 6 – In Córdoba, in the Spanish kingdom of Andalusia, members of the nobility and the general public revolt against the Spanish inquisitor Diego Rodriguez de Lucero and General Inquisitor Diego de Deza. The mob liberates the people incarcerated at the Córdoba prison.
October 7 – Pope Julius II issues a bull excommunicating Giovanni II Bentivoglio from the Roman Catholic Church, who had dominated the Italian city state of Bologna.
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