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As Vice President, Biden filled in for the President to deliver several weekly addresses:
- "Restore the American Dream" (4 December 2010)
- "A Single Act of Kindness" (28 May 2011)
- "Increase the Pace" (5 November 2011)
- "Deserve Enough Pay" (29 March 2014)
- "Given a Fair Shot" (6 September 2014)
- "Pleased and Excited" (3 January 2015)
- "Crisis to Recovery" (11 April 2015)
- "We Stand As One" (21 November 2015)
- "The Courage of Our Actions" (9 July 2016)
- "The Defining Difference" (30 July 2016) along with Timothy K. Lewis
- "The Ones We Can Save" (29 October 2016)
- "The Immense Possibilities" (19 November 2016)
As President, Biden restarted the addresses on 2021-10-06 in the form of short videos called A Weekly Conversation:
- A Weekly Conversation: On the Line with Michele (2021-02-06)
- A Weekly Conversation: On the Line with Samir and Neal (2021-02-13)
- President Biden Calls NASA (2021-02-20)
- A Weekly Conversation: On the Line with Erica (2021-02-27)
- A Weekly Conversation: On the Line with Tammy (2021-03-06)
- A Weekly Conversation: With Mike at W. S. Jenks & Son.webm (2021-03-13)
- A Weekly Conversation: On the Line with Jocelyn (2021-03-20)
- A Weekly Conversation: With Megan Rapinoe and Margaret Purce (2021-03-27)
- A Weekly Conversation: Americans Ask the White House About the American Jobs Plan (2021-04-03)
- A Weekly Conversation on The American Jobs Plan (2021-04-10)
- A Weekly Conversation: On the Line with Susie from Texas (2021-04-17)