Paul Modrich: American biochemist
Paul Lawrence Modrich (born June 13, 1946) is an American biochemist.
He is known for his research on DNA mismatch repair. He received the Nobel Prize in Chemistry 2015, together with Aziz Sancar and Tomas Lindahl.
Paul L. Modrich | |
|---|---|
 Paul L. Modrich, Nobel Laureate in chemistry in Stockholm December 2015 | |
| Born | Paul Lawrence Modrich June 13, 1946 Raton, New Mexico, U.S. |
| Nationality | United States |
| Alma mater | MIT, Stanford University (PhD) |
| Known for | Clarification of cellular resistance to carcinogens |
| Awards | Nobel Prize in Chemistry (2015) |
| Scientific career | |
| Fields | DNA mismatch repair |
| Institutions | |
| Website | Paul L. Modrich |
He was born on June 13, 1946, in Raton, New Mexico to Laurence and Margaret Modrich. He has a younger brother Dave. His father was a biology teacher and coach for basketball, football and tennis at Raton High School where he graduated in 1964.
His work
He works primarily on strand-directed mismatch repair. His lab demonstrated how DNA mismatch repair serves as a copyeditor to prevent errors from DNA polymerase. Matthew Meselson previously proposed the existence of recognition of mismatches. Modrich performed biochemical experiments to study mismatch repair in E. coli. They later searched for proteins associated with mismatch repair in humans.
References
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