Poliovirus Receptor-Related 2

NECTIN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3R0N, 4DFH, 4DFI, 4HZA
Identifiers
Aliases	NECTIN2, CD112, HVEB, PRR2, PVRR2, PVRL2, nectin cell adhesion molecule 2
External IDs	OMIM: 600798 MGI: 97822 HomoloGene: 86092 GeneCards: NECTIN2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,889,223 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,484,408 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right lobe of liver; ; gallbladder; ; body of stomach; ; upper lobe of left lung; ; right adrenal gland; ; left lobe of thyroid gland; ; minor salivary glands; ; right lobe of thyroid gland; ; left uterine tube;
	Top expressed in
	yolk sac; ; duodenum; ; crypt of lieberkuhn of small intestine; ; jejunum; ; stomach; ; lip; ; pyloric antrum; ; external carotid artery; ; internal carotid artery; ; gastric mucosa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	coreceptor activity; virus receptor activity; protein binding; identical protein binding; signaling receptor binding; cell adhesion molecule binding; protein heterodimerization activity; protein homodimerization activity;
Cellular component	integral component of membrane; membrane; cell-cell junction; focal adhesion; plasma membrane; integral component of plasma membrane; cell surface; zonula adherens; extracellular exosome; apical junction complex; cell-cell contact zone;
Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; sperm mitochondrion organization; cell recognition; positive regulation of immunoglobulin mediated immune response; regulation of viral entry into host cell; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of mast cell activation; cell adhesion; acrosome assembly; cytoskeleton organization; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; cilium organization; establishment of mitochondrion localization; spermatid development; regulation of immune response; fertilization; spermatid nucleus differentiation; susceptibility to T cell mediated cytotoxicity; viral process; cell part morphogenesis; adherens junction organization; positive regulation of natural killer cell mediated cytotoxicity; homophilic cell adhesion via plasma membrane adhesion molecules; viral entry into host cell; signal transduction; positive regulation of T cell receptor signaling pathway; virion attachment to host cell;
	Sources:Amigo / QuickGO
Orthologs
	5819
	19294
	ENSG00000130202
	ENSMUSG00000062300
	Q92692
	P32507
	NM_001042724; NM_002856
	NM_001159724; NM_008990
	NP_001036189; NP_002847
	NP_001153196; NP_033016
	Wikidata
View/Edit Human	View/Edit Mouse

Function

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

References

External links

PVRL2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q92692 (Human Nectin-2) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: P32507 (Mouse Nectin-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Poliovirus Receptor-Related 2

Function

See also

References

Further reading

External links

Tags:

🔥 Trending searches on Wiki English: