Glucokinase Regulator

GCKR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PXS, 4BBA, 4MQU, 4OLH, 4MSU, 4BB9, 4OHP, 4OP1, 4OP3, 4OHM, 4OHO, 4MRO, 4PX2, 4PX3, 4PX5, 4OHK, 4LY9, 4OP2
Identifiers
Aliases	GCKR, FGQTL5, GKRP, glucokinase (hexokinase 4) regulator, glucokinase regulator
External IDs	OMIM: 600842 MGI: 1096345 HomoloGene: 1139 GeneCards: GCKR
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,523,684 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	31,484,658 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; pancreatic ductal cell; ; gastric mucosa; ; body of stomach; ; islet of Langerhans; ; gallbladder; ; body of pancreas; ; ascending aorta; ; left coronary artery;
	Top expressed in
	left lobe of liver; ; right lobe of liver; ; pineal gland; ; ciliary body; ; secondary oocyte; ; iris; ; yolk sac; ; retinal pigment epithelium; ; morula; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; fructose-6-phosphate binding; carbohydrate derivative binding; enzyme inhibitor activity; enzyme binding; carbohydrate binding;
Cellular component	nucleoplasm; nucleus; cytosol; cytoplasm; mitochondrion;
Biological process	negative regulation of glucokinase activity; response to fructose; triglyceride homeostasis; urate metabolic process; carbohydrate derivative metabolic process; regulation of glycolytic process; carbohydrate metabolic process; glucose homeostasis; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	2646
	231103
	ENSG00000084734
	ENSMUSG00000059434
	Q14397
	Q91X44
	NM_001486
	NM_144909; NM_001374741
	NP_001477
	NP_659158; NP_001361670
	Wikidata
View/Edit Human	View/Edit Mouse

Function

This gene encodes a protein belonging to the GCKR subfamily of the SIS (sugar isomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008].

Glucokinase Regulator

Function

References

Further reading

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