Cdk4

division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. CDK4 is a member of the cyclin-dependent kinase family. The protein encoded...

selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Palbociclib was the first CDK4/6 inhibitor to be approved as a cancer therapy. It is...

The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine kinase...

The US FDA approved the first drug of this type, palbociclib (Ibrance), a CDK4/6 inhibitor, in February 2015, for use in postmenopausal women with breast...

this trigger, cyclin D binds to existing CDK4/6, forming the active cyclin D-CDK4/6 complex. Cyclin D-CDK4/6 complexes in turn mono-phosphorylates the...

was developed by Eli Lilly and it acts as a CDK inhibitor selective for CDK4 and CDK6. It was designated as a breakthrough therapy for breast cancer by...

transcriptional CDKs, which mediate gene transcription. CDK1, CDK2, CDK3, CDK4, CDK6, and CDK7 are directly related to the regulation of cell-cycle events...

alternative name p16INK4a refers to its role in inhibiting cyclin-dependent kinase CDK4. p16 is also known as: p16INK4A p16Ink4 Cyclin-dependent kinase inhibitor...

with Cdk4 and Cdk6 (Cdk4/6) which are both phosphorylated by ERK. The transition from G1 to S phase is coordinated by the activity of Cyclin D-Cdk4/6, which...

crystalline powder that is soluble in aqueous acids. Ribociclib is the only CDK4/CDK6 inhibitor with a proven benefit on overall survival across all three...

molecule CDK4/6 inhibitor that is being studied for the treatment of cancer. It has a similar structure to abemaciclib but is more selective for CDK4/6 over...

This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This...

(p16INK4a, p15INK4b, p18INK4c, p19INK4d) are inhibitors of CDK4 (hence their name INhibitors of CDK4), and of CDK6. The other family of CKIs, CIP/KIP proteins...

targets of cyclin D/cdk4 phosphorylation during the G1 to S transition. This might suggest a possible compensation of cdk3 activity by cdk4, especially in...

signal for the rise of cyclin D levels, which then binds to Cdk4 and Cdk6 to form the CyclinD:Cdk4/6 complex. This complex is known to inactivate Rb by phosphorylation...

potentially tumor-causing gene when overexpressed) located at band 15 and CDK4 (a gene that when overexpressed promotes the development of various tumors)...

cause gradual accumulation of cyclin D, which complexes with CDK4/6. Active cyclin D-CDK4/6 complex induces release of E2F transcription factor, which...

transformation and disease states such as cancer. During this transition, G1 cyclin D-Cdk4/6 dimer phosphorylates retinoblastoma releasing transcription factor E2F...

cyclin/CDK complex. CDK4/6 is inhibited by p15Ink4b, p16Ink4a, p18Ink4c, and p19Ink4d. These inhibitors prevent the binding of CDK4/6 with cyclin D (Cánepa...

regulating the cell cycle. p16 inhibits cyclin dependent kinases 4 and 6 (CDK4 and CDK6) and thereby activates the retinoblastoma (Rb) family of proteins...