Als2

ALS2
Identifiers
Aliases	ALS2, ALS2CR6, ALSJ, IAHSP, PLSJ, alsin Rho guanine nucleotide exchange factor, alsin Rho guanine nucleotide exchange factor ALS2
External IDs	OMIM: 606352 MGI: 1921268 HomoloGene: 23264 GeneCards: ALS2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	201,782,112 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	59,276,390 bp
RNA expression pattern
	Top expressed in
	cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; cerebellar vermis; ; tibialis anterior muscle; ; deltoid muscle; ; sural nerve; ; middle temporal gyrus; ; Achilles tendon; ; Brodmann area 46;
	Top expressed in
	cerebellar cortex; ; morula; ; yolk sac; ; spermatid; ; superior frontal gyrus; ; spermatocyte; ; pharynx; ; proximal tubule; ; duodenum; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; guanyl-nucleotide exchange factor activity; protein serine/threonine kinase activator activity; protein binding;
Cellular component	cytoplasm; vesicle; centrosome; membrane; postsynaptic density; intracellular membrane-bounded organelle; growth cone; ruffle; dendritic spine; axon; neuronal cell body; dendrite; early endosome; neuron projection; lamellipodium; cytosol; protein-containing complex;
Biological process	protein localization; neuron projection morphogenesis; synaptic transmission, glutamatergic; axonogenesis; locomotory behavior; vesicle organization; regulation of GTPase activity; cell death; in utero embryonic development; behavioral fear response; response to oxidative stress; endosome organization; endosomal transport; positive regulation of GTPase activity; receptor recycling; neuromuscular junction development; Rac protein signal transduction; regulation of Rho protein signal transduction; regulation of endosome size; positive regulation of Rac protein signal transduction; positive regulation of protein kinase activity; positive regulation of protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	57679
	74018
	ENSG00000003393
	ENSMUSG00000026024
	Q96Q42
	Q920R0
	NM_001135745; NM_020919
	NM_001159948; NM_028717; NM_146109
	NP_001129217; NP_065970
	NP_001153420; NP_082993; NP_666221
	Wikidata
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