Purine History
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Purine is a heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together. It is water-soluble. Purine also...
Nucleotide (section Purine ribonucleotide synthesis)linked. Purines, however, are first synthesized from the sugar template onto which the ring synthesis occurs. For reference, the syntheses of the purine and...
ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. High blood concentrations...
Alkaloid (redirect from Purine alkaloid)This group includes terpene-like and steroid-like alkaloids, as well as purine-like alkaloids such as caffeine, theobromine, theacrine and theophylline...
Adenine (redirect from 6-Amino-purine)Adenine (/ˈædɪnɪn/) (symbol A or Ade) is a purine nucleobase. It is one of the four nucleobases in the nucleic acids of DNA, the other three being guanine...
Allopurinol (section History)allopurinol's effect. Allopurinol is a purine analog; it is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an inhibitor...
Hyperuricemia (category Inborn errors of purine-pyrimidine metabolism)amount of urate in the body depends on the balance between the amount of purines eaten in food, the amount of urate synthesised within the body (e.g., through...
Caffeine (redirect from 1,3,7-trimethyl-1H-purine-2,6(3H,7H)-dione 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione)inhibition of phosphodiesterase. Caffeine is a bitter, white crystalline purine, a methylxanthine alkaloid, and is chemically related to the adenine and...
Mercaptopurine (category Purine antagonists)Mercaptopurine is a purine antimetabolite or purine antagonist as such inhibits DNA synthesis by inhibiting the production of the purine containing nucleotides...
Chargaff's rules (category History of genetics)equal to the amount of thymine. Further, a 1:1 stoichiometric ratio of purine and pyrimidine bases (i.e., A+G=T+C) should exist. This pattern is found...
Lesch–Nyhan syndrome (category Inborn errors of purine-pyrimidine metabolism)fluids. The combination of increased synthesis and decreased utilization of purines leads to high levels of uric acid production. This results in both high...
chemists who were working at the Burroughs Wellcome Co. in Tuckahoe, many purine analogues were tested, culminating in the discovery of 6-mercaptopurine...
Azathioprine (category Purine antagonists)during pregnancy may result in harm to the baby. Azathioprine belongs to the purine analogues subclass of antimetabolites family of medications. It works via...
external stresses. In 1884, Hermann Emil Fischer proposed the structure of purine, a key structure in many biomolecules, which he later synthesized in 1898...
humans and other hominids), it is a product of oxidation of uric acid by purine catabolism. After birth, it is the predominant means by which nitrogenous...- Gout (category Inborn errors of purine-pyrimidine metabolism)regularly drink beer or sugar-sweetened beverages; eat foods that are high in purines such as liver, shellfish, or anchovies; or are overweight. Diagnosis of...
Ribonucleotide (section History)uracil (U). The nitrogenous bases are classified into two parent compounds, purine and pyrimidine. The general structure of a ribonucleotide consists of a...
1,3,7-Trimethyluric acid (redirect from 1,3,7-trimethyl-9H-purine-2,6,8-trione)7-Trimethyluric acid, also referred to as trimethyluric acid and 8-oxy-caffeine, is a purine alkaloid that is produced in some plants and occurs as a minor metabolite...
Nucleic acid (section History)(chains) of nucleotides. Each nucleotide consists of three components: a purine or pyrimidine nucleobase (sometimes termed nitrogenous base or simply base)...
Fludarabine (category Purine antagonists)Fludarabine is a purine analogue and antineoplastic agent. It is generally used as its 5-O-phosphorylated form known as fludarabine phosphate, sold under...
- peasant stories; and "Kolumbine," in which is described how a fallen woman purines herself through her love for a man. Among his numerous romances we may
- Purines are biologically synthesized as nucleotides (bases attached to ribose 5-phosphate). A key regulatory step is the production of ribose-5-phospho-α-D-ribosyl