Pax6 Function
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downstream effectors of Pax6 functions. PAX6 protein function is highly conserved across bilaterian species. For instance, mouse PAX6 can trigger eye development...
syndrome). Several different mutations may affect the PAX6 gene. Some mutations appear to inhibit gene function more than others, with subsequent variability...
gene is Pax6/eyeless, which controls eye formation in all animals. It has been found to produce eyes in mice and Drosophila, even if mouse Pax6/eyeless...
Cerebral cortex (section Function)regulation of expression of Emx2 and Pax6 and represent how the cerebral cortex can become specialized for different functions. Rapid expansion of the cortical...
2003). "Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene". Developmental...
due to independent variants of Pax6 arising in both cephalopods and vertebrates. Cephalopods contain five variants of Pax6 in their genomes which independently...- Pax genes in eye evolution: A cnidarian PaxB gene uniting Pax2 and Pax6 functions" (PDF). Developmental Cell. 5 (5): 773–785. doi:10.1016/S1534-5807(03)00325-3...
MAML1, MEF2C, MEF2D, MYBL2, Mdm2, MyoD, MEF2A, NCOA6, NFATC2, NPAS2, P53, PAX6, PCNA, PROX1, PTMA, PPARA, PPARG, RORA, RELA, SMAD1, SMAD2, SMAD7, SNIP1...
transcription factor Pax6 and changes the pattern of neurite extension in cerebellar granule cells through its binding to Pax6". The Journal of Biological...
subsequent development of the optic vesicles regulated by the PAX6 and LHX2 proteins. The role of Pax6 in eye development was elegantly demonstrated by Walter...
Arthropod eye (section Eyes and functions)among the most important genes for patterning the eyes of insects are the Pax6 homologs eyeless (ey) and twin of eyeless (toy). Together, these genes drive...- ISSN 0027-8424. PMC 41780. PMID 7761391. Hanson, Isabel M. (2003-12-01). "PAX6 and Congenital Eye Malformations". Pediatric Research. 54 (6): 791–796. doi:10...
G, et al. (February 2008). "Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence". PLOS Genetics. 4 (2): e29. doi:10.1371/journal...
receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription". Molecular Pharmacology. 73 (2):...
2003). "Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene". Developmental...
retinoic acid. Retinoic acid is required ventrally along with Shh to induce Pax6 and Olig2 during differentiation of motor neurons. Three main ventral cell...
MID1 (section MID1 main cellular functions)have been reported: Alpha4 (α4) and its associated phosphatase, PP2A, Fu, Pax6 and BRAF35. Together with α4 and PP2A, MID1 can form a ternary complex in...
Sonic hedgehog protein (section Function)of transcription factors—Nkx2.2, Olig2, Nkx6.1, Nkx6.2, Dbx1, Dbx2, Irx3, Pax6, and Pax7—that is regulated by the SHH gradient. These transcription factors...
some may be highly counter-intuitive. For example, deep homologies like the pax6 genes that control the development of the eyes of vertebrates and arthropods...
in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6". Mol. Cell. Biol. 22 (13): 4702–13. doi:10.1128/MCB.22.13.4702-4713.2002...
- a light sensitive spot, they did have some regulatory genes in common... PAX6 for example, but that had to effectively independently recruit all the rest
- include: ALX4, ARX, HESX1, HOXA13, LMX1B, MSX1, MSX2, OTX2, PAX2, PAX3, PAX6, PAX8, PHOX2A, PHOX2B, PITX2, POU3F4, PROP1, SHOX, SIX1, SIX3, SIX5, TGIF1