Naturally Occurring Dna Damage Role of ATR and ATM
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- DNA damage can occur naturally or via environmental factors, but is distinctly different from mutation, although both are types of error in DNA. DNA damage...
allow DNA repair to occur before the cell cycle progresses. First, two kinases, ATM and ATR are activated within 5 or 6 minutes after DNA is damaged. This...- The DNA damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring DNA damage. Damage in this context...
breaks, and works with ATM to ensure genome integrity. ATR is a serine/threonine-specific protein kinase that is involved in sensing DNA damage and activating...- Genome instability (section DNA Replication Defects)reductions in expression of DNA repair genes. Because endogenous (metabolically-caused) DNA damage is very frequent, occurring on average more than 60...
BRCA1 (category DNA repair)by ATM/ATR kinases both in vitro and in vivo. ATM/ATR are kinases activated by DNA damage. Mutation of serine residues may affect localization of BRCA1...
Double-strand break repair model (category DNA repair)PMID 23610439. Blackford AN, Jackson SP (June 2017). "ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response". Molecular Cell. 66 (6): 801–817...- Programmed cell death (redirect from Cell senescence and death)non-homologous end joining, the catalytic subunit of DNA-PK; (5) homologous recombinational repair, BRCA1, ATM, ATR, WRN, BLM, Tip60, p53. The BCR-ABL oncogene...
Molecular lesion (section DNA Damage Response)lesion is damage to the structure of a biological molecule such as DNA, RNA, or protein. This damage may result in the reduction or absence of normal function...
BRCA2 (category DNA repair)repair of chromosomal damage with an important role in the error-free repair of DNA double strand breaks. If BRCA1 or BRCA2 itself is damaged by a BRCA...- Ataxia–telangiectasia (category DNA replication and repair-deficiency disorders)an important role in DNA damage repair and signaling and is required to recruit ATM to the sites of DNA double strand breaks. Mre11 and Nbs1 are also...
- cellular response to DNA damage are ATM and ATR kinases (ataxia telangiectasia mutated) through the regulation of phosphorylation of over 700 proteins.