MKK4

1126/science.7716521. PMID 7716521. "P45985 | SWISS-MODEL Repository". "MKK4 (human)". www.phosphosite.org. Retrieved 2020-10-28. Nishina H, Vaz C, Billia...

MAP2K4 (a.k.a. MKK4) MAP2K5 (a.k.a. MKK5) MAP2K6 (a.k.a. MKK6) MAP2K7 (a.k.a. MKK7) The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK...

kinase subdomain VIII. Activation is carried out by two MAP kinase kinases, MKK4 and MKK7, and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases...

Kim, JE; Kwon, JY; Lee, DE; Kang, NJ; Heo, YS; Lee, KW; Lee, HJ (2009). "MKK4 is a novel target for the inhibition of tumor necrosis factor-alpha-induced...

TAOK1, etc.). In addition, some MAP2K enzymes may activate both p38 and JNK (MKK4), while others are more specific for either JNK (MKK7) or p38 (MKK3 and MKK6)...

pathway. In collaboration with another mitogen-activated protein kinase kinase MKK4, MKK7 work as crucial transducers upstream of JNK signaling. Through joint...

edwardinae ARKive: borneophrys-edwardinae BioLib: 180638 BOLD: 794425 CoL: MKK4 GBIF: 2424814 iNaturalist: 65127 ITIS: 774817 Megophrys edwardinae Wikidata:...

Martindale JL, Rinker-Schaeffer CW, Gorospe M (October 2009). "Increased MKK4 abundance with replicative senescence is linked to the joint reduction of...

2003). "Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways". The Journal of Biological...

p38 MAP kinase is activated by two other MAP kinases known as MKK3 and MKK4. MKK4 is also known to activate the JNK MAP kinase, however, MKK3 is unique...

certain pathogens. Experimentation has proposed that the MAPK module MEKK1-MKK4/MKK5-MPK3/MPK6 may be responsible for flg22 signal transmission. All of the...

cellular pathways, which contribute to its metastasis-suppressing functions. MKK4 is a suppressor active in prostate and ovarian cancers It apparently functions...

0404445101. PMC 522008. PMID 15469925. Ahn YH, Kurie JM (October 2009). "MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin...

humans: Licofelone, CBS-3595, Skepinone-L, and, currently, HRX-215 as an MKK4 inhibitor for the treatment of acute and chronic liver disease. The focus...

MEKK4 can specifically phosphorylate and activate PRKMK6 (MKK6) and SERK1 (MKK4), MAPKKs that activate CSBP2 (p38α) and JNK, respectively but cannot phosphorylate...

kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7". Biochem. J. 352 Pt 1 (Pt 1): 145–54. doi:10.1042/0264-6021:3520145...

PMID 11836244. Yang JJ (2002). "Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest"...

nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four...

Holzman LB (Apr 1999). "The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate". J. Biol. Chem. 274 (15): 10195–202. doi:10.1074/jbc.274.15...

Holzman LB (1999). "The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate". J. Biol. Chem. 274 (15): 10195–202. doi:10.1074/jbc.274.15...