- Polonium, a chemical element
- Po, the hero of the movie Kung Fu Panda
- Po (Teletubby), one of the Teletubbies
- Pô, a town in Burkina Faso
- Po, Asturias or Poo (until 2005), a parish of Llanes municipality, in Asturias, Spain
- Po River, in Italy
- Po River (Virginia), in the U.S. state of Virginia
- .po, an abbreviation of Portable Object and filename extension of text translation files used in software localization
- Po' boy (from "Poor Boy"), a type of submarine sandwich from New Orleans
- an abbreviation for Chamber pot
- Po!, an indie band from Leicester
- Sally Po, a fictional character in the Anime series, "Gundam Wing"
- pò (魄), the material manifestation of the soul according to Chinese belief
PO is also an acronym or abbreviation which may stand for:
- Post office
- Pau, France
- PO postcode area centred on Portsmouth in the UK
- In Armed services:
- Petty Officer, a Non-Commissioned Officer rank in many navies
- Pilot Officer, a junior commissioned rank the British and many Commonwealth air forces
- In Aviation, Polar Air Cargo, IATA airline designator
- Petrol Ofisi, Turkish petroleum distribution company
- Pareto optimality
- Purchase order
- Principal Only, a type of collateralized mortgage obligation
- Perfect Orange, a third wave ska band
- In law:
- Presiding Officer
- Parole/Probation officer
- In medicine, per os or per orem, literally "by mouth", a direction to take a medication by mouth
- In philosophy, Provocative operation, coined by Edward De Bono and part of a Lateral thinking technique
- In politics:
- In Science and Technology:
- Pilkington Optronics, now Thales Optronics
- Product Owner in the Scrum development process
- Specimen code, collection of the Zoological Institute of the Russian Academy of Sciences, St Petersburg
- Petaoctet, a unit of information or computer storage
- In transportation, Chemin de Fer de Paris à Orléans, an old railway created to link Paris to Orléans
- Po, A Fracción of Barragan from the anime and manga series Bleach
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