ରିଭାରୋକ୍ସାବାନ

ରିଭାରୋକ୍ସାବାନ
Clinical data
Trade names	Xarelto, others
Synonyms	BAY 59-7939
AHFS/Drugs.com	monograph
MedlinePlus	a611049
data	EU EMA: yes; US DailyMed: Rivaroxaban;
Pregnancy; category	AU: C ; ;
Routes of; administration	By mouth
ATC code	B01AF01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	80–100%; Cmax = 2–4 hours (10 mg oral)
Metabolism	CYP3A4, CYP2J2 and CYP-independent mechanisms
Elimination half-life	5–9 hours in healthy subjects aged 20 to 45
Excretion	2/3 metabolized in liver and 1/3 eliminated unchanged
Identifiers
	IUPAC name (S)-5-chloro-N-{[2-oxo-3-[4-(3-oxomorpholin-4-yl); phenyl]oxazolidin-5-yl]methyl} thiophene-2-carboxamide;
CAS Number	366789-02-8 ;
PubChem CID	6433119;
IUPHAR/BPS	6388;
DrugBank	DB06228 ;
ChemSpider	8051086 ;
UNII	9NDF7JZ4M3;
KEGG	D07086 ;
ChEBI	CHEBI:68579;
ChEMBL	CHEMBL198362 ;
PDB ligand	RIV (PDBe, RCSB PDB);
ECHA InfoCard	100.210.589
Chemical and physical data
Formula	C19H18ClN3O5S
Molar mass	୪୩୫.୮୮ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1COCCN1c2ccc(cc2)N3C[C@@H](OC3=O)CNC(=O)c4ccc(s4)Cl;
	InChI InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1 ; Key:KGFYHTZWPPHNLQ-AWEZNQCLSA-N ;
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ରିଭାରୋକ୍ସାବାନ (ଇଂରାଜୀ ଭାଷାରେ Rivaroxaban), ବ୍ରାଣ୍ଡ ନାମ ଜାରେଲ୍ଟୋ/ Xarelto, ଏକ ରକ୍ତ ପତଳାକାରୀ ଔଷଧ ଯାହା ରକ୍ତ ଜମାଟ ପ୍ରତିରୋଧ ନିମନ୍ତେ ଦିଆଯାଏ । ନିର୍ଦ୍ଦିଷ୍ଟ ଭାବରେ ଏହା ଗଭୀର ଶିରା ଥ୍ରୋମ୍ବୋସିସ୍ ଏବଂ ଫୁସଫୁସ ଏମ୍ବୋଲିଜ୍ମର ଚିକିତ୍ସା ପାଇଁ ଓ ରକ୍ତ ଜମାଟ ପ୍ରତିରୋଧ ନିମନ୍ତ ଆଟ୍ରିଆଲ୍ ଫାଇବ୍ରିଲେସନ ଏବଂ ହିପ କିମ୍ବା ଆଣ୍ଠୁ ଅସ୍ତ୍ରୋପଚାର ପରବର୍ତ୍ତୀ ସମୟରେ ବ୍ୟବହୃତ ହୁଏ | ଏହା ପାଟିରେ ଦିଆଯାଏ |

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରକ୍ତସ୍ରାବ ହୁଏ | ଅନ୍ୟାନ୍ୟ ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମେରୁଦଣ୍ଡ ହେମାଟୋମା ଏବଂ ଆନାଫାଇଲକ୍‌ସିସ ହୋଇପାରେ | ଗର୍ଭାବସ୍ଥାରେ ଏବଂ ସ୍ତନ୍ୟପାନରେ ବ୍ୟବହାର ସୁରକ୍ଷିତ କି ନାହିଁ ତାହା ଅସ୍ପଷ୍ଟ ରହିଛି। ୱାରଫାରିନ ତୁଳନାରେ ଏହାର ଅନ୍ୟାନ୍ୟ ଔଷଧ ସ‌ହିତ ଅଳ୍ପ ପ୍ରତିକ୍ରିୟା ହୁଏ । ଏହା ଫ୍ୟାକ୍ଟର ଏକ୍ସଏର କାର୍ଯ୍ୟକଳାପକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟ କରେ |

ରିଭାରୋକ୍ସାବାନ ୨୦୦୭ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୨୦୧୧ ମସିହାରେ ଆମେରିକାରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ୨୦୨୪ ମସିହା ପର୍ଯ୍ୟନ୍ତ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ହେବ ନାହିଁ | ଏକ ମାସ ଯୋଗାଣ ନିମନ୍ତେ ବ୍ରିଟେନରେ ୨୦୨୦ ମସିହାରଏଏନଏଚଏସର £ ୫୦ ଏହା ବାବଦରେ ଖର୍ଚ୍ଚ ହୋଇଥିଲା । ଆମେରିକାରେ ଏହି ପରିମାଣର ହୋଲସେଲ୍ ମୂଲ୍ୟ ଆମେରିକୀୟ 430 ଡଲାର ଥିଲା । ୨୦୧୭ ମସିହାରେ ଏହା ଆମେରିକାର ୧୦୯ ତମ ସାଧାରଣ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଛଅ ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା |

ଆଧାର

↑
↑
↑
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ "Xarelto: Summary of Product Characteristics". Bayer Schering Pharma AG. 2008. Retrieved February 11, 2009.
↑ Abdulsattar Y, Bhambri R, Nogid A (May 2009). "Rivaroxaban (xarelto) for the prevention of thromboembolic disease: an inside look at the oral direct factor xa inhibitor". P & T. 34 (5): 238–44. PMC 2697099. PMID 19561868.
↑ "Rivaroxaban Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
↑ ^୭.୦ ^୭.୧ ^୭.୨ ^୭.୩ ^୭.୪ "Rivaroxaban Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
↑ "Rivaroxaban Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.
↑ Kiser, Kathryn (2017). Oral Anticoagulation Therapy: Cases and Clinical Correlation (in ଇଂରାଜୀ). Springer. p. 11. ISBN 9783319546438.
↑ "Generic Xarelto Availability". Drugs.com. Retrieved 9 May 2017.
↑ "Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations". www.accessdata.fda.gov. Retrieved 2019-04-24.
↑ "Bayer, J&J Win Ruling That Upholds Patent for Xarelto Drug". 2019-04-22. Retrieved 2019-04-24.
↑ BNF (80 ed.). London: BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. pp. 137–139. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Rivaroxaban - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

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[Drugs.com_pregnancy-1] ↑

[Xarelto_EPAR-2] ↑

[Xarelto_FDA_label-3] ↑

[Xarelto_SPC-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ "Xarelto: Summary of Product Characteristics". Bayer Schering Pharma AG. 2008. Retrieved February 11, 2009.

[5] Abdulsattar Y, Bhambri R, Nogid A (May 2009). "Rivaroxaban (xarelto) for the prevention of thromboembolic disease: an inside look at the oral direct factor xa inhibitor". P & T. 34 (5): 238–44. PMC 2697099. PMID 19561868.

[AHFS2019-6] "Rivaroxaban Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[autogen1-7] ୭.୦ ^୭.୧ ^୭.୨ ^୭.୩ ^୭.୪ "Rivaroxaban Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[Preg2019-8] "Rivaroxaban Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.

[Kiser2017-9] Kiser, Kathryn (2017). Oral Anticoagulation Therapy: Cases and Clinical Correlation (in ଇଂରାଜୀ). Springer. p. 11. ISBN 9783319546438.

[10] "Generic Xarelto Availability". Drugs.com. Retrieved 9 May 2017.

[11] "Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations". www.accessdata.fda.gov. Retrieved 2019-04-24.

[12] "Bayer, J&J Win Ruling That Upholds Patent for Xarelto Drug". 2019-04-22. Retrieved 2019-04-24.

[BNF80-13] BNF (80 ed.). London: BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. pp. 137–139. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[NADAC2019-14] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.

[ref-15] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[ref1-16] "Rivaroxaban - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

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