Zymosan
Zymosan is a beta-glucan with repeating glucose units connected by β-1,3-glycosidic linkages.
It binds to TLR 2 and Dectin-1 (CLEC7A). Zymosan is a ligand found on the surface of fungi, like yeast.
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| Identifiers | |
|---|---|
| ChemSpider |
|
| ECHA InfoCard | 100.029.737 |
CompTox Dashboard (EPA) | |
| Properties | |
| (C6H10O5)x | |
| Molar mass | Variable |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Zymosan is prepared from yeast cell walls and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels, suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection, suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action.
References
External links
- Zymosan at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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