U5 Spliceosomal Rna
U5 snRNA is a small nuclear RNA (snRNA) that participates in RNA splicing as a component of the spliceosome.
It forms the U5 snRNP (small nuclear ribonucleoprotein) by associating with several proteins including Prp8 - the largest and most conserved protein in the spliceosome, Brr2 - a helicase required for spliceosome activation, Snu114, and the 7 Sm proteins. U5 snRNA forms a coaxially-stacked series of helices that project into the active site of the spliceosome. Loop 1, which caps this series of helices, forms 4-5 base pairs with the 5'-exon during the two chemical reactions of splicing. This interaction appears to be especially important during step two of splicing, exon ligation.
| U5 spliceosomal RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of U5 | |
| Identifiers | |
| Symbol | U5 |
| Rfam | RF00020 |
| Other data | |
| RNA type | Gene; snRNA; splicing |
| Domain(s) | Eukaryota |
| GO | GO:0000351 GO:0000353 GO:0005682 GO:0046540 |
| SO | SO:0000395 |
| PDB structures | PDBe |
References
Further reading
- Zwieb C (January 1997). "The uRNA database". Nucleic Acids Research. 25 (1): 102–3. doi:10.1093/nar/25.1.102. PMC 146409. PMID 9016512.
- Thomas J, Lea K, Zucker-Aprison E, Blumenthal T (May 1990). "The spliceosomal snRNAs of Caenorhabditis elegans". Nucleic Acids Research. 18 (9): 2633–42. doi:10.1093/nar/18.9.2633. PMC 330746. PMID 2339054.
External links
This article uses material from the Wikipedia English article U5 spliceosomal RNA, which is released under the Creative Commons Attribution-ShareAlike 3.0 license ("CC BY-SA 3.0"); additional terms may apply (view authors). Content is available under CC BY-SA 4.0 unless otherwise noted. Images, videos and audio are available under their respective licenses.
®Wikipedia is a registered trademark of the Wiki Foundation, Inc. Wiki English (DUHOCTRUNGQUOC.VN) is an independent company and has no affiliation with Wiki Foundation.