- Frank Mitchell (sportsman, born 1872) (1872–1935), English cricketer and rugby union player
- Sir Frank Herbert Mitchell (1878–1951), English cricketer and member of the British Royal household, 1920–1931
- Frank Mitchell (goalkeeper) (1890–1958), Scottish football goalkeeper (Liverpool, Everton, Motherwell)
- Frank Mitchell (actor) (1905–1991), American actor
- George Francis Mitchell (1912–1997), known as Frank, Irish geologist and naturalist
- Frank Mitchell (sportsman, born 1922) (1922–1984), Australian-born association footballer and county cricketer
- Frank Mitchell (politician) (born 1925), politician in British Columbia, Canada
- Frank Mitchell (musician) (c. 1945–c. 1971), American jazz saxophonist
- Frank Mitchell (prisoner) (c. 1929–1966), English criminal known as "The Mad Axeman" and associate of the Kray twins
- Frank Mitchell (presenter) (born 1960), Northern Irish TV presenter
- Frank Mitchell (striker), soccer player
- Frank N. Mitchell (1921–1950), US Marine and Medal of Honor recipient
- W. Franklin Mitchell, American politician
- Frank Mitchell (bowls) (born 1911), South African lawn bowler
- F. W. D. Mitchell (1845–1936), Australian civil servant and health writer
See also
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