File:Iron BBB.jpg
Jump to navigation
Jump to search
Size of this preview: 455 × 600 pixels. Other resolutions: 182 × 240 pixels | 364 × 480 pixels | 700 × 923 pixels.
Original file (700 × 923 pixels, file size: 165 KB, MIME type: image/jpeg)
Captions
Captions
Intracerebral metabolism of iron and its neuro‐bioavailability.
Summary[edit]
| Description |
English: Iron crosses the blood–brain barrier (BBB) either by:
• The transcytosis pathway, where the complex “diferric Fe3+-transferrin-transferrin receptor 1 (TfR1)” undergoes endocytosis and exocytosis from the luminal pole to the cerebral extracellular matrix (ECM) and interstitial fluid. • The facilitated transporter pathway, where endothelial cells internalize the complex “diferric Fe3+-transferrin-transferrin receptor 1 (TfR1)” in endosome, reduce ferric Fe3+ ion to ferrous Fe2+ ion by STEAP3 enzyme and then Fe2+ ion crosses the endosomal membrane thanks to DMT1. Fer²+ is then exported to the extracellular matrix (ECM) and interstitial fluid, via ferroportin coupled with ceruloplasmin (Note that transferrin is not only a plasmatic protein and choroid plexuses can secrete it). |
| Date | |
| Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175715/ |
| Author | Christian Berthou, Jean Paul Iliou, and Denis Barba |
Licensing[edit]
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 23:37, 30 January 2024 | | 700 × 923 (165 KB) | PecMo (talk | contribs) | Uploaded a work by Christian Berthou, Jean Paul Iliou, and Denis Barba from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175715/ with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on en.wikipedia.org
