File:Fmicb-10-01490-g001.jpg

English: Schematic diagrams of a vesicular stomatitis virus (VSV) virion and Non-segmented negative strand (NNS) RNA viral genomes. (A) A VSV particle is composed of a cellular lipid bilayer, viral RNA genome, and five viral proteins: nucleo- (N), phospho- (P), matrix (M), glyco- (G), and large (L) proteins. The virus particle contains a ribonucleoprotein (RNP) composed of N–RNA and RNA-dependent RNA polymerase (RdRp) complexes. (B) The gene organization of negative-strand genomes of typical NNS RNA viruses [measles virus (MeV), human respiratory syncytial virus (HRSV), Ebola virus (EBOV), Borna disease virus 1 (BoDV-1), and Nyamanini virus (NYMV)] belonging to different families is depicted in the 3′ to 5′ order. Transcription initiation and termination sites are shown by bent arrows and red vertical lines, respectively. The positions of negative-strand open reading frames are shown by colored boxes. The L genes encode an L protein with RdRp, GDP polyribonucleotidyltransferase (PRNTase), and methyltransferase (MTase, except for nuclear-replicating viruses) domains. A scale bar is shown at the bottom (knt, kilo nucleotides).