Nidogen-1

Both nidogen-1 and nidogen-2 are essential components of the basement membrane alongside other components such as type IV collagen, proteoglycans (heparan sulfate and glycosaminoglycans), laminin and fibronectin.

NID1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NDX
Identifiers
Aliases	NID1, NID, nidogen 1, entactin
External IDs	OMIM: 131390 MGI: 97342 HomoloGene: 1878 GeneCards: NID1
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.3 Start 235,975,830 bp End 236,065,109 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 A1|13 5.26 cM Start 13,612,136 bp End 13,686,854 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium gastric mucosa lower lobe of lung left uterine tube right lung pericardium pylorus canal of the cervix placenta subcutaneous adipose tissue Top expressed in epididymis external carotid artery internal carotid artery left lung lobe trophoblasts dermis conjunctival fornix atrium atrioventricular valve uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function laminin-1 binding calcium ion binding laminin binding collagen binding extracellular matrix binding proteoglycan binding extracellular matrix structural constituent Cellular component extracellular matrix extracellular region basement membrane extracellular exosome cell periphery extracellular space collagen-containing extracellular matrix Biological process cell-matrix adhesion extracellular matrix disassembly extracellular matrix organization cell adhesion glomerular basement membrane development basement membrane organization positive regulation of cell-substrate adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4811 18073 Ensembl ENSG00000116962 ENSMUSG00000005397 UniProt P14543 P10493 RefSeq (mRNA) NM_002508 NM_010917 RefSeq (protein) NP_002499 NP_035047 Location (UCSC) Chr 1: 235.98 – 236.07 Mb Chr 13: 13.61 – 13.69 Mb PubMed search
Wikidata
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Nidogen-1 is a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes. Structurally it (along with perlecan) connects the networks formed by collagens and laminins to each other. It may also play a role in cell interactions with the extracellular matrix.

Mutations in NID1 cause autosomal dominant Dandy–Walker malformation with occipital encephalocele (ADDWOC).

Nidogen-1 has been shown to interact with FBLN1.