Pharmacology Cmax

It is a standard measurement in pharmacokinetics.

C_max is the opposite of C_min, which is the minimum (or trough) concentration that a drug achieves after dosing. The related pharmacokinetic parameter t_max is the time at which the C_max is observed.

After an intravenous administration, C_max and t_max are closely dependent on the experimental protocol, since the concentrations are always decreasing after the dose. But after oral administration, C_max and t_max are dependent on the extent, and the rate of drug absorption and the disposition profile of the drug. They could be used to characterize the properties of different formulations in the same subject.

Short term drug side effects are most likely to occur at or near the C_max, whereas the therapeutic effect of drug with sustained duration of action usually occurs at concentrations slightly above the C_min.^{[citation needed]}

The C_max is often measured in an effort to show bioequivalence (BE) between a generic and innovator drug product. According to the FDA, drug quality bioavailability (BA) and BE rely on pharmacokinetic measurements such as AUC and C_max that are reflective of systemic exposure.

• C_avg (pharmacology)
• Area under the curve (pharmacokinetics)