Aftph

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Clathrin-binding box of Aftiphilin
Clathrin-binding box of Aftiphilin
Identifiers
Symbol	Clathrin_bdg
Pfam	PF15045
InterPro	IPR029205
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

AFTPH
Identifiers
Aliases	AFTPH, Nbla10388, aftiphilin
External IDs	MGI: 1923012 HomoloGene: 9764 GeneCards: AFTPH
Gene location (Human)
Chr.	Chromosome 2 (human)
End	64,593,005 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	20,691,589 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; sperm; ; cardia; ; cerebellar vermis; ; pylorus; ; parotid gland; ; nipple; ; superior surface of tongue; ; thoracic diaphragm; ; trachea;
	Top expressed in
	spermatocyte; ; submandibular gland; ; lacrimal gland; ; dorsomedial hypothalamic nucleus; ; habenula; ; olfactory epithelium; ; left colon; ; thymus; ; cerebellar cortex; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	clathrin binding;
Cellular component	AP-1 adaptor complex; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; nucleus; cytoplasm; trans-Golgi network membrane;
Biological process	protein transport; intracellular transport;
	Sources:Amigo / QuickGO
Orthologs
	54812
	216549
	ENSG00000119844
	ENSMUSG00000049659
	Q6ULP2
	Q80WT5
	NM_001002243; NM_017657; NM_203437
	NM_001252503; NM_001290545; NM_181411
NP_001002243; NP_060127; NP_982261; NP_001362898; NP_001362899;
	NP_001362900; NP_001362901; NP_001362902
	NP_001239432; NP_001277474; NP_852076
	Wikidata
View/Edit Human	View/Edit Mouse

It forms a stable complex with p200 and synergin gamma. It contains a clathrin box with two known clathrin-binding sequence motifs, is involved in vesicle trafficking and is found in many eukaryotes.