Phosphoribosylamine
Phosphoribosylamine (PRA) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA.
The vitamins thiamine and cobalamin also contain fragments derived from PRA.
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| Other names PRA | |
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3D model (JSmol) | |
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| ChemSpider | |
| MeSH | Phosphoribosylamine |
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CompTox Dashboard (EPA) | |
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| Properties | |
| C5H12NO7P | |
| Molar mass | 229.125 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Phosphoribosyl pyrophosphate (PRPP)
It is the product of the enzyme amidophosphoribosyltransferase which attaches ammonia from glutamine to phosphoribosyl pyrophosphate (PRPP) at its anomeric carbon:
- PRPP + glutamine → PRA + glutamate + PPi
The biosynthesis pathway next combines PRA with glycine in a process driven by ATP giving glycineamide ribonucleotide (GAR). The enzyme phosphoribosylamine—glycine ligase catalyses the reaction forming an amide bond:
- PRA + glycine + ATP → GAR + ADP + Pi
See also
References
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