Chicken buses from Guatemala City leave approximately every hour, from 6AM to 4PM, and cost only a few US dollars. However, the ride is long, and it can be quite uncomfortable if the bus gets crowded (which it almost certainly will).

Alternatively, you can take a bus to Los Encuentros, and change there. A bus from Los Encuentros to Sololá costs Q2 (quetzales) and from there you can take another to Panajachel, for Q3.50.

Many tourist agencies will arrange tourist buses transport to Panajachel. A minibus from Antigua to Panajachel is US$12 per person each way, though some among the number of agents offering the service could charge US$20-25.

Adrenalina diagonally across from the post office (oficina de correos) has a good reputation.

Panajachel is quite small, and you can walk practically anywhere within 20 minutes. Small three-wheel taxis (or tuk-tuks) continually circle the few streets, and cost Q5 for any destination in Panajachel, Q10 if the ride requires going off the delta (uphill), for example to the Nature reserve (3 people negotiated a ride back for only Q20).

Private shuttle boats ("lanchas") to other cities around the lake, such as Jaibalito, San Marcos La Laguna, and San Pedro La Laguna, leave regularly from the "embarcadero" at the foot of the main street, Calle Santander. The cost is about Q15-30 one way (Q5-15 for Central Americans). The larger public ferries are cheaper (Q25 for foreigners) but they only go to Santiago Atitlan (from foot of Calle Rancho Grande, east of Santander) and San Pedro (from foot of Calle del Embarcadero, west of Santander).

Boats to Santiago Atitlan leave from another dock every 30 mins, and take around 25 mins to cross the lake. It costs Q25, although locals pay less. To get to the dock, go to the end of Calle Santander, turn left and go until the end of the road, then turn right.

There is no bus station yet, but chicken buses, taxis and shuttle buses congregate at the intersection of Calle Principal and Calle Santander. Fletes (Toyota pickups) can be found near the market. They are the cheapest way to get to nearby towns. They are a great way to meet the indigenous people, who are their best customers.

Chicken bus to Solola costs Q5 (Dec 2011) & Q20 to Xela (gringos charged Q30 along with eye-to-eye lies that it's the normal price for everyone; Dec 2011).

• Casa Cakchiquel, Calle 14 Febrero (Corner of Santander and 14 Febrero), ☏ +502 7762 09 69, [email protected]. Built in 1948, Casa Cakchiquel was one of the first hotels on the lake and according to legend, Ernersto "Che" Guevara, Ingrid Bergman, and other intellectuals, artists, and writers enjoyed the house at its best. Today the house has been restored and features a fair trade store, rotating exhibits, and a vintage photo and postcard gallery. It is also home to organizations Thirteen Thread and Radio 5. WiFi free. 
• Lake Atitlan Villages If you are staying in Panajachel it is quite possible to explore a number of the villages around the lake in one day with a combination of lanchas, tuk-tuks and walking as follows. Catch a lancha to San Pedro La Laguna and walk to San Juan La Laguna along the road, before climbing to Mirador Kaqasiiwan. Back down on the road catch a San Pablo La Laguna-registered tuk-tuk (tuk-tuks are only allowed to go to the two villages either side of where they are registered) to San Marcos La Laguna. From there, catch a lancha to Jaibalito, before walking along the lovely footpath eastwards to Santa Cruz La Laguna. Catch a Lancha back to Panajachel

• Volunteer
  • Robert Muller LIFE School; LIFE's mission is to provide a top-notch, multicultural education to expat and indigenous children alike. LIFE School is the only English-speaking non-profit school in Guatemala. 44% of its current students receive some form of financial assistance.
  • You can also volunteer for free with Mayan Families. The organization provides support to Indigenous and Ladino Guatemalans through education scholarships, emergency food and medical services, donations, etc. You can install new stoves, teach preschoolers, translate, cook food for their Elderly Feeding Program, help sort donations and more!

In addition to the aforementioned volunteer opportunities, Panajachel has a number of other Non-Governmental Organizations that accept volunteers on a no-fee basis. A couple of these include: Mayan Traditions and Estrella de Mar.

• ATI Divers, ☏ +502 5706-4117. In the nearby village of Santa Cruz La Laguna is ATI Divers. Diving in the lake is interesting as this is high altitude diving into a fresh water lake. Also, due to the fact the volcanic activity is present there are hot spots under the bed of the lake. At various points it is possible to feel the heat with your hands by digging them into the floor of the lake. The life in the lake consists of crabs, fish, snails and plants. ATI Divers do the PADI open water course for US$220 over four days. PADI advanced is $200. Fun dives are $30/$50. They also do an altitude dive course for $80. Located on the same site and run by the same people is La Iguana Perdida. 
• Kayaking, Many of the lake side resorts own recreational and sea kayaks that they are more than willing to rent. But if you're not staying at a resort the public beach in Panajachel in front of Hotel Del Lago has a small two story tower that rents kayaks. The mobility of the kayaks and warm waters provide endless stopping points for private cliff-side diving and swimming as well as a close up look at some very fancy homes. Prices for the day are around Q100-200 for a two-person kayak. Q50 at La Iguana Perdida backpacker's hotel! Los Elementos Adventure Center has an excellent kayaks, and offer guided tours as well as hourly rentals. Full moon and sunrise paddles are a unique way to enjoy the lake. 2-4 day around the lake tours are an affordable adventure if you are looking for something special. 5359.8328
• Xocomil Tours, Street Pier Tzanjuyu 4-86, ☏ +502 4937 2368, [email protected]. Offers quality bike rentals for village around the lake also offers boat tours, trekking around the lake, climbing volcanoes, coffee tour, and other adventures ideal for adventure tourism can be organizing in Panajachel. 
• Nature Reserve (Reserva Natural Atitlán), ☏ +502 7762 2565. for Q55 the nearby Reserva Natural Atitlán, or Atitlan Nature Reserve and butterfly sanctuary is part of an old coffee finca. You can see monkeys, coatimundis and many species of birds, walk on hanging bridges towards the waterfall or the private beach. Stay in their "green" Hotel Atitlan. The oldest house in the area (~1700 AD) and a stone, German-built mill (~1880s AD) are on the property. You can ride eight zip lines across the valley with a great view of the property, the lake and the volcanoes and then ride into the forest for Q220 (which also includes the normal Q55 admission to the Reserva). The equipment and gear is very secure and you always have two guides. 
• Säq B'ey Tour Operator, ☏ +502 3600 1160. Private boat tours to explore the more remote areas of the lake, or for private transportation to any area of the lake. Ideal for birdwatching, visiting the geothermal hot springs, or just for a swim in the middle of the lake. Also 

Mayan boys, girls, women & men walk the streets of Pana from morning until night selling authentic Mayan good such as textiles, paintings, jewelry, clothing, accessories and even nuts. They can be quite hard sellers and will very often approach people dining inside of restaurants along the main roads (Calle Santander especially). It is common to be approached a dozen times while eating and sometimes a refusal will result in a begging appeal for money to buy food. Usually a very firm 'No thanks' will do the trick. Prices of the goods offered seem to compete fairly well with shops selling similar goods in Pana. If you see something you like, it is still highly recommended to haggle. Try and pay around half to two thirds of the original asking price, as a guide.

If you're interested in buying traditional Mayan clothes or textiles, the towns around the lake are great places to do so. The quality of textiles here is significantly higher than in most other places of the country. The best quality goods are found in Santiago Atitlan, on the south side of the lake.

(Note: Before choosing a restaurant and/or hotel stop by the Nature Reserve and pick up their list of hotels who have joined the recycling collective. Please boycott those places that have not, as Pana has a huge pollution problem. This includes Pana Rock)

• Guajimbo's, Calle Santander. (Uruguayan) The menu notes that their vegetables are disinfected and they use purified water for drinking water and ice. They have the best steaks: huge, grilled to perfection with creative toppings. Live music most evenings at 19:00.
• Las Chinitas, Plaza Los Patios, Calle Santander. Serving Chinese, Japanese, and Malaysian food in a variety of combinations. On one night the crowd was almost entirely foreigners, with a folk band of gringos playing 1960s and 70s American hits. They use purified water for vegetables and drinking. 
• Circus Bar, Av Los Arboles (only a few steps from Calle Principal). Good pizza. Typically features live bands at night on weekends. Well known place, now with another branch in Antigua. 
• Sunset Cafe (at the foot of Calle Santander), ☏ +502 7762-0003. The tables are in an open room with gorgeous views over the lake. Cuisine includes Mexican and international dishes. Come for the view, not for the food - it's not that good. Prices are mid-range, with entrees at Q30-40. Enjoy an exotic cocktail or a variety of beers from the bar. The menu notes that their vegetables are disinfected and they use purified water for drinking water and ice. Live Music every night of the week. 
• Dina's Chocolate, If you are a connoisseur of fine chocolates and sweets, make sure you search stop by the small store in downtown Pana, where the calle Santander forks into a "Y" A very special variety is the chile lime! Pricy, but a rare break from Nestle bars in this part of the world!
• Ricassoli Pizza Steak House, Calle Santander, ☏ +502 5770-3100. Cuisine: Italian/traditional Guatemalan. Provides a delicious typical breakfast plate. 
• Restaurante Hana, Centro Comercial El Patio on Calle Santander, ☏ +502 4298-1415. 12-3PM 6-8PM Closed Mondays. Serves traditional Japanese dining in a beautiful, authentic Japanese restaurant. 
• Towards the bottom of Calle Santander and near the bus stop on Calle Principal there are a number of street vendors selling tacos, sweet corn, sweet nuts and other snack foods. These are a good cheap option for the budget traveller. The "food court" is on Calle Santander, in front of the elementary school (big curved roof), across the street from the Mayanet Internet cafe. Street vendors can be found there all hours of the day and evening.

In Pana it is almost a tradition (at least for Guatemalans) to drink and walk up and down the Santander street with a "Litro" in their hands. A "Litro" is a 1 liter bottle of beer. Usually Gallo or Cabro brand. But you can get virtually any drink you ask for.

While you may still drink in the streets in Panajachel, it is no longer as common; only during certain festivities or special events will the party spill out in to the street.

• La Palapa, Calle Principal y Los Arboles. Provides wi-fi to customers. Q10 Cuba Libres, beer, and tequila during happy hour in addition to daily specials. They also feature live music, trivia, and weekend barbecues. There is a hostel on site; ask one of the staff members for details. 
• Cafe-Bar above Tierra Maya Tours, Calle Santander, ☏ +502 7762-6076. Provides wi-fi to customers. 2-for-1 Cuba Libres (rum, coke & lime wedge) for Q25 & Black Russians (blanco y negro) for Q30. (updated Dec 2011)
• Pana Rock Cafe. Buy a cubetazo of your favorite beer (or peruse the extensive drink menu), meet some locals and listen to Latin Rock or a live band with an ambiance unrivaled by any bar in the country. (updated Aug 2020)

As you might expect from a regional tourist hub, Panajachel has a range of accommodations at all price levels. Some hotels outside Panajachel proper are also listed in the Nearby section.

• Hotel Jere, Av. Rancho Grande (150 metros from the playa publica), ☏ +502 7762 2781. Q75 per person per night for room with shower, private room, WiFi, and they arrange tour around the Atitlan lake. 
• Mario's Rooms, Calle Santander, ☏ +502 7762-1313. (Feb 2011) Q80 per person/night for room with no shower (shared, not ensuite, and located at the ground floors—might be problematic if you ate at street stalls!), including breakfast, and drinking water. So friendly and helpful. A beautiful courtyard, nice rooms. Free WiFi, albeit a slow but adequate connection. 
• Hospedaje Sanchez, On the Calle el Chali (one block from the Calle Santander), ☏ +502 7762-2224. If you do not mind shared bathrooms, then this is an excellent place. It is clean, quiet, and comfortable. Cost is about US$5 per night. It is particularly nice to have an upstairs room, where the window on the back wall lets in gentle breezes from the lake. Great lake views from the roof. Convenient to the main road, but you will feel that you are deeply in Guatemala. The Sanchez family are very sweet people, who respect your privacy, but are willing to help you with anything. 
• Villa Lupita, Budget option US$5 per room with shared bathroom. Lovely, family-owned place. Clean and cared for.
• Grand Hotel, Calle Principal, ☏ +502 7762-2940. Can get busy at weekends due to an influx of visitors from Guatemala City, this hotel has comfortable rooms, a beautiful garden, free WiFi, swimming pool, and restaurant. 
• Primavera. A mid-scale hotel right in the middle of Panajachel. Renovated in 2000, most of the rooms are on the second floor. Around US$40 per night. 
• Hotel Utz Jay, Calle 15e de febreo (between Calle Santander and Calle Ranchos Grande), [email protected]. Quiet, nicely decorated rooms with Guate fabrics, artwork, set around a beautiful courtyard with birds and hammocks. Honor system for beers and sodas. Private baths with hot water, and a sauna on the grounds. Continental breakfast included with the room. You can also book boat and other tours here. The owner (Marie Lissette) is very helpful and aims to please. US$45. (updated Nov 2023)
• Hotel Casa Loma, (on a small side street off Calle Rancho Grande near the Calle de Buenas Nuevas).Has private parking.
• Atitlan Solutions (Vacation rentals in Guatemala), Calle Santander, Comercial San Rafael, Local 4 and 6, ☏ +502 7762 0959. Also providing an option for long term vacation rentals (week/month/year). 
• Hotel El Sol, Salida a Santa Catarina Palopó, Barrio Jucanyá, ☏ +502 7762-6090, [email protected]. Check-in: 14:00, check-out: 13:00. Very clean, quiet and comfortable hotel. It's a bit of a walk from the centre of the town, but well worth it for the free WiFi, (small) hot tub, kitchen and sushi restaurant. Dormitory room Q50, private room from Q150, long term stay discounts. 
• Casa Linda (near the top of Santander on the right hand side, across from Habitat for Humanity & Marvelus Hostel, beside Hospedaje Montufar). Nice, clean and friendly place. Not very social but fabulous hosts. Water from shower head was hot & bathroom reasonably clean. Garden in centre court was lush & gorgeous. Q50 for a single; a 3-person private w/ shared bath Q147. 
• 14.739929-91.1584631 Posada Don Miguel, Callejon Los Quenun 3 (down narrow south-leading alleyway towards eastern end of Callejon Los Quenun), ☏ +502 5331 6275. Nice, clean and friendly place with guest kitchen, good showers, Wi-Fi. 14.739929, -91.158463. Q230 for double with private bath. (updated Nov 2023)

Nearby edit

• Hotel San Buenaventura de Atitlan, Antigua Finca San Buenventura (From Panajachel a mile away, take the road to Sololá and veer left after the first climb, follow the signs.), ☏ +502 7762 2559. Surrounded by an old coffee plantation. 10 houses offer double rooms, or units with double rooms, living and dining rooms plus a fully equipped kitchen. It is flanked by two rivers, has a private beach and it is only a 4 min walk to the Atitlán Nature Reserve. US$80-110, special pricing during the off-season. 
• Hotel Atitlan, Antigua Finca San Buenventura (about a half mile outside of Panajachel). 62-room lakeside hotel with extensive, beautifully-designed gardens leading right up to the lake, an aviary with macaws, parrots, hummingbirds. The hotel lobby has a theme of antique Catholic wood carvings. The outdoor unheated pool offers a great view of the volcanoes. It's located about a five min walk from the Atitlan Nature Reserve and the butterfly sanctuary. US$125-225. 
• Reserva Natural Atitlan, Antigua Finca San Buenventura, ☏ +502 7762 2565. 12 min walk from Panajachel proper, the Nature Reserve has units surrounded by nature with private deck and a campground with bathrooms. US$65-70. 
• Las Tarrales Nature Reserve (on the road towards Cocales), ☏ +502 5919 8882, fax: +502 2478 4901, [email protected]. A protected area with tourism and lodging. It goes nearly to the top of Volvan Atitlan. You can see an old coffee "benefacio", where freshly picked coffee is still processed. Many very rare birds have been spotted on the property, as well as a giant local species of bamboo that grows as big as telephone poles, with its feet in hot volcano water. Various lodging options, from doubles and triples to dorm rooms to camping. US$20-30. 

Chichicastenango has a famous market every Thursday and Sunday.